Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.77 |
| ▸ | PDE4A | P27815 | 1/20 | 0.77 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.76 |
| ▸ | BLM | P54132 | 2/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
| ▸ | GSR | P00390 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | MFN2 | O95140 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3341311 | 1.00 | ADRA2A (0.77) | ADRA2APDE4AADRA1AALDH1A1SMN1; SMN2 | |
| Lomustine SCHEMBL3995 | 0.87 | ADRA2A (1.00) | ADRA2APDE4AADRA1AALDH1A1SMN1; SMN2 | |
| Lomustine SCHEMBL868328 | 0.87 | ADRA2A (1.00) | ADRA2APDE4AADRA1AALDH1A1SMN1; SMN2 | |
| Semustine SCHEMBL4500 | 0.86 | ALDH1A1 (1.00) | ADRA2APDE4AADRA1AALDH1A1SMN1; SMN2 | |
| Semustine SCHEMBL4959160 | 0.86 | ALDH1A1 (1.00) | ADRA2APDE4AADRA1AALDH1A1SMN1; SMN2 | |
| SCHEMBL21693655 | 0.86 | ADRA2A (0.75) | ADRA2APDE4AADRA1AALDH1A1SMN1; SMN2 | |
| SCHEMBL21693656 | 0.86 | ADRA2A (0.75) | ADRA2APDE4AADRA1AALDH1A1SMN1; SMN2 | |
| Semustine SCHEMBL28854924 | 0.85 | ALDH1A1 (0.97) | ADRA2APDE4AADRA1AALDH1A1SMN1; SMN2 | |
| Lomustine SCHEMBL28262197 | 0.84 | ADRA2A (0.94) | ADRA2APDE4AADRA1AALDH1A1SMN1; SMN2 | |
| Lomustine SCHEMBL28159683 | 0.83 | ADRA2A (0.91) | ADRA2APDE4AADRA1AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080287541-A1 | Kit for Treatment of Cancer | REDOXIA ISRAEL LTD. (IL) | 2008-11-20 | — | — | US | claimed |
| EP-1755679-A2 | KIT FOR TREATMENT OF CANCER | Redoxia Israel Limited (IL) | 2007-02-28 | — | — | EP | claimed |
| WO-2005107370-A2 | KIT FOR TREATMENT OF CANCER | REDOXIA ISRAEL LTD (IL) | 2005-11-17 | — | — | WO | claimed |
| US-20100162416-A1 | Multi-stage stem cell carcinogenesis | STEMLIFELINE, INC. (US) | 2010-06-24 | — | — | US | disclosed |
| WO-2010037134-A2 | MULTI-STAGE STEM CELL CARCINOGENESIS | STEMLIFELINE, INC. (US) | 2010-04-01 | — | — | WO | disclosed |
| US-20080287541-A1 | Kit for Treatment of Cancer | REDOXIA ISRAEL LTD. (IL) | 2008-11-20 | — | — | US | disclosed |
| EP-1755679-A2 | KIT FOR TREATMENT OF CANCER | Redoxia Israel Limited (IL) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005107370-A2 | KIT FOR TREATMENT OF CANCER | REDOXIA ISRAEL LTD (IL) | 2005-11-17 | — | — | WO | disclosed |