Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 3/20 | 0.34 |
| ▸ | PPARG | P37231 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | XBP1 | P17861 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3336835 | 0.83 | HRH4 (0.37) | KMT2AMEN1PPARAPPARGPPARD | |
| Hydrochloric Acid SCHEMBL3342562 | 0.82 | HRH4 (0.36) | KMT2AMEN1PPARAPPARGPPARD | |
| SCHEMBL3341580 | 0.79 | ADORA1 (0.37) | MAPTTDP1NPSR1KMT2AMEN1 | |
| SCHEMBL3336440 | 0.75 | MEN1 (0.34) | KMT2AMEN1GAAALDH1A1LMNA | |
| SCHEMBL3337996 | 0.75 | CTSK (0.39) | MAPTKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL3336893 | 0.75 | MEN1 (0.34) | KMT2AMEN1GAAALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL3340086 | 0.74 | CTSK (0.39) | MAPTKMT2AMEN1KDM4E | |
| SCHEMBL3339240 | 0.74 | ROCK2 (0.39) | MAPT | |
| SCHEMBL3342606 | 0.74 | PPARG (0.33) | MAPTKMT2APPARAPPARGGAA | |
| Hydrochloric Acid SCHEMBL3336721 | 0.73 | ROCK2 (0.39) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324261-B2 | Histidine derivatives | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 2012-12-04 | — | — | US | disclosed |
| US-20100152459-A1 | NOVEL HISTIDINE DERIVATIVES | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 2010-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152459-A1 | NOVEL HISTIDINE DERIVATIVES | HRH4, HNMT, HRH3 | MAPT 3851/4885CACNA1B 1698/4885TDP1 3497/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.