Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHUK | O15111 | 5/20 | 0.68 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.56 |
| ▸ | CDC7 | O00311 | 5/20 | 0.54 |
| ▸ | CDK9 | P50750 | 1/20 | 0.52 |
| ▸ | IKBKB | O14920 | 5/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.51 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.51 |
| ▸ | CSF1R | P07333 | 4/20 | 0.51 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.49 |
| ▸ | GSK3B | P49841 | 2/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.49 |
| ▸ | BTK | Q06187 | 1/20 | 0.48 |
| ▸ | CCNC | P24863 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.47 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28163150 | 0.86 | MKNK2 (0.68) | CHUKSIRT3TDP1PKMYT1CDC7 | |
| SCHEMBL3346124 | 0.83 | PIK3CB (0.67) | CHUKSIRT3TDP1PKMYT1MKNK2 | |
| SCHEMBL7120106 | 0.82 | IKBKB (0.66) | CHUKPKMYT1IKBKBMKNK2MKNK1 | |
| SCHEMBL3343643 | 0.81 | MKNK1 (0.54) | CHUKSIRT3TDP1PKMYT1IKBKB | |
| SCHEMBL3226601 | 0.81 | MKNK1 (0.78) | SIRT3TDP1MKNK2MKNK1BTK | |
| SCHEMBL5302307 | 0.81 | CHUK (1.00) | CHUKPKMYT1CDC7CDK9IKBKB | |
| SCHEMBL5306999 | 0.81 | CHUK (0.70) | CHUKPKMYT1CDC7CDK9IKBKB | |
| SCHEMBL3382180 | 0.79 | CHUK (0.68) | CHUKPKMYT1CDC7CDK9IKBKB | |
| SCHEMBL3386608 | 0.79 | CHUK (0.68) | CHUKPKMYT1CDC7CDK9IKBKB | |
| SCHEMBL3342287 | 0.78 | MKNK2 (0.47) | CHUKSIRT3TDP1IKBKBMKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100160384-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | ROCHE PALO ALTO LLC | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160384-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | P2RY1, P2RX6, P2RX3 | CHUK 1510/4885SIRT3 315/4885TDP1 1578/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.