Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 4/20 | 0.66 |
| ▸ | BRD4 | O60885 | 1/20 | 0.51 |
| ▸ | ACMSD | Q8TDX5 | 3/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.50 |
| ▸ | HNF4A | P41235 | 2/20 | 0.50 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.50 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.50 |
| ▸ | DHFR | P00374 | 1/20 | 0.50 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.48 |
| ▸ | CHUK | O15111 | 3/20 | 0.47 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.47 |
| ▸ | DHODH | Q02127 | 3/20 | 0.47 |
| ▸ | GSTA1 | P08263 | 1/20 | 0.46 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.45 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.45 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.45 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38652464 | 0.85 | MKNK1 (0.67) | IKBKBBRD4ACMSDMCL1HNF4A | |
| SCHEMBL10024279 | 0.85 | MCL1 (0.63) | IKBKBACMSDMCL1HNF4ADHFR | |
| SCHEMBL5255978 | 0.85 | MCL1 (0.63) | IKBKBACMSDMCL1HNF4ADHFR | |
| SCHEMBL1404169 | 0.85 | GSTA1 (0.58) | IKBKBACMSDMCL1HNF4ADHFR | |
| SCHEMBL7125464 | 0.83 | MAPT (0.53) | IKBKBBRD4ACMSDMCL1HNF4A | |
| SCHEMBL5332435 | 0.82 | IKBKB (0.72) | IKBKBBRD4ACMSDMCL1HNF4A | |
| SCHEMBL30595681 | 0.82 | IKBKB (0.72) | IKBKBBRD4ACMSDMCL1HNF4A | |
| SCHEMBL3342702 | 0.82 | CHUK (0.68) | IKBKBMKNK1MKNK2CHUKIKBKE | |
| SCHEMBL8531138 | 0.82 | SLC9A1 (0.54) | IKBKB | |
| SCHEMBL12607537 | 0.81 | IKBKB (0.44) | IKBKBBRD4MCL1MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113631541-B | Preparation method of amide compound and application of amide compound in medicine field | 上海华汇拓医药科技有限公司 | 2024-10-01 | — | — | CN | claimed |
| CN-113631541-B | Preparation method of amide compound and application of amide compound in medicine field | 上海华汇拓医药科技有限公司 | 2024-10-01 | — | — | CN | disclosed |
| CN-115197202-B | EZH2 covalent inhibitor and preparation method and application thereof | 四川大学 | 2024-01-26 | — | — | CN | disclosed |
| WO-2023104155-A1 | LIGAND COMPOUNDS FOR E3 UBIQUITIN LIGASE, PROTEIN DEGRADERS DEVELOPED ON BASIS OF LIGAND COMPOUNDS, AND USES THEREOF | 标新生物医药科技(上海)有限公司 | 2023-06-15 | — | — | WO | disclosed |
| CN-115197202-A | EZH2 covalent inhibitor and preparation method and application thereof | 四川大学 | 2022-10-18 | — | — | CN | disclosed |
| EP-4053122-A1 | COMPOUND COMPRISING EZH2 INHIBITOR AND E3 LIGASE BINDER AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING EZH2-ASSOCIATED DISEASE COMPRISING SAME AS ACTIVE INGREDIENT | Daegu-Gyeongbuk Medical Innovation Foundation (KR) | 2022-09-07 | — | — | EP | disclosed |
| EP-2906537-A2 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme, Inc. (US) | 2015-08-19 | — | — | EP | disclosed |
| WO-2014062733-A2 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme, Inc. (US) | 2014-04-24 | — | — | WO | disclosed |
| JP-2003206270-A | METHOD OF PRODUCTION FOR 2-METHYL-5-PHENYLBENZONITRILE | SUMITOMO CHEM CO LTD | 2003-07-22 | — | — | JP | disclosed |