Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 1/20 | 0.67 |
| ▸ | CCNC | P24863 | 2/20 | 0.56 |
| ▸ | CDK8 | P49336 | 2/20 | 0.56 |
| ▸ | CHUK | O15111 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.46 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.42 |
| ▸ | WNT3A | P56704 | 2/20 | 0.42 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.42 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21923189 | 0.84 | PIK3CB (0.51) | PIK3CBCCNCCDK8DYRK1AMKNK2 | |
| SCHEMBL3342702 | 0.83 | CHUK (0.68) | CCNCCDK8CHUKDYRK1AMKNK1 | |
| SCHEMBL3346810 | 0.81 | MKNK1 (0.52) | PIK3CBCHUKMKNK1MKNK2SIRT3 | |
| SCHEMBL3342661 | 0.80 | TGFBR1 (0.46) | PIK3CBCCNCCDK8CHUKMKNK1 | |
| SCHEMBL11153504 | 0.79 | PIK3CB (0.72) | PIK3CBCCNCCDK8CHUKPIK3R2 | |
| SCHEMBL3342287 | 0.79 | MKNK2 (0.47) | PIK3CBCHUKMKNK1MKNK2SIRT3 | |
| SCHEMBL25307513 | 0.77 | PIK3CB (0.58) | PIK3CBCCNCCDK8CHUKDYRK1A | |
| SCHEMBL3342234 | 0.77 | KMO (0.47) | PIK3CBMKNK1MKNK2SIRT3TDP1 | |
| SCHEMBL10320333 | 0.77 | BRD4 (0.46) | PIK3CBCHUKMKNK1MKNK2SIRT3 | |
| SCHEMBL29695035 | 0.76 | PIK3CB (0.61) | PIK3CBCCNCCDK8DYRK1ASIRT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100160384-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | ROCHE PALO ALTO LLC | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160384-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | P2RY1, P2RX6, P2RX3 | PIK3CB 3229/4885CCNC 3113/4885CDK8 2497/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.