Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT1 | P04628 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.37 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4927936 | 0.79 | MKNK1 (0.44) | SMN1; SMN2RAB9ABRD4BRD9TP53 | |
| SCHEMBL27430479 | 0.78 | HRH4 (0.42) | WNT1GSK3BDYRK1ASMN1; SMN2RAB9A | |
| SCHEMBL2476613 | 0.77 | TSHR (0.43) | WNT1GSK3BDYRK1ASMN1; SMN2TP53 | |
| SCHEMBL3343755 | 0.77 | RAB9A (0.44) | TDP1SMN1; SMN2RAB9ALMNANPC1 | |
| SCHEMBL3346118 | 0.77 | SYK (0.40) | DYRK1ATDP1SIRT3ENPP3RAB9A | |
| SCHEMBL30967607 | 0.77 | NPC1 (0.47) | SMN1; SMN2RAB9ABRD4LMNAPDE4D | |
| SCHEMBL3348705 | 0.75 | SMN1; SMN2 (0.44) | WNT1GSK3BDYRK1ATDP1SIRT3 | |
| SCHEMBL3342287 | 0.74 | MKNK2 (0.47) | TDP1SIRT3ENPP3SMN1; SMN2RAB9A | |
| SCHEMBL6609423 | 0.74 | TRPV1 (0.42) | WNT1GSK3BDYRK1ATDP1SMN1; SMN2 | |
| SCHEMBL3346669 | 0.74 | MKNK1 (0.53) | DYRK1ATDP1SIRT3MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100160384-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | ROCHE PALO ALTO LLC | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160384-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | P2RY1, P2RX6, P2RX3 | WNT1 3548/4885GSK3B 3653/4885DYRK1A 1152/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.