Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.43 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.43 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.43 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.38 |
| ▸ | KLRK1 | P26718 | 1/20 | 0.38 |
| ▸ | MICA | Q29983 | 1/20 | 0.38 |
| ▸ | RAET1L | Q5VY80 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29037233 | 0.83 | MKNK1 (0.50) | SMN1; SMN2ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL3375136 | 0.78 | ABCC9 (0.50) | SMN1; SMN2ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL3348740 | 0.78 | ENPP3 (0.41) | SMN1; SMN2SYKMKNK1MKNK2ALDH1A1 | |
| SCHEMBL3377975 | 0.77 | PARP1 (0.51) | SMN1; SMN2SYKBRD4PDE4DPDE7A | |
| SCHEMBL3348708 | 0.76 | SMN1; SMN2 (0.50) | SMN1; SMN2ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL23023473 | 0.75 | PPM1B (0.47) | SMN1; SMN2ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL3343751 | 0.75 | WNT1 (0.39) | SMN1; SMN2SYKMKNK1MKNK2KMT2A | |
| SCHEMBL26696260 | 0.74 | PARP1 (0.44) | SMN1; SMN2ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL3344435 | 0.73 | PKMYT1 (0.47) | MKNK1MKNK2SIRT3TDP1BRD4 | |
| SCHEMBL3342117 | 0.73 | PDE4D (0.39) | SMN1; SMN2SYKMKNK1MKNK2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100160384-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | ROCHE PALO ALTO LLC | 2010-06-24 | — | — | US | disclosed |
| EP-1943235-A1 | ARYLUREA DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Novartis AG (CH) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007048771-A1 | ARYLUREA DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | NOVARTIS AG (CH) | 2007-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160384-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | P2RY1, P2RX6, P2RX3 | SMN1; SMN2 2819/4885ABCC9 160/4885ABCC8 107/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.