Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.39 |
| ▸ | NR5A2 | O00482 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.34 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346669 | 0.84 | MKNK1 (0.53) | MKNK1MKNK2SYKPARP1KMT2A | |
| SCHEMBL3343238 | 0.82 | MEN1 (0.46) | KMT2AMEN1SMN1; SMN2PDE4DALDH1A1 | |
| SCHEMBL3346285 | 0.82 | HDAC3 (0.38) | SYKKMT2AMEN1NPC1HDAC1 | |
| SCHEMBL3343791 | 0.81 | SMN1; SMN2 (0.41) | NR5A2KMT2AMEN1NPC1SMN1; SMN2 | |
| SCHEMBL3342747 | 0.77 | HDAC3 (0.46) | PDK2KMT2AMEN1HDAC1ALDH1A1 | |
| SCHEMBL3343071 | 0.77 | HDAC3 (0.39) | MKNK1MKNK2HDAC1SIRT3TDP1 | |
| SCHEMBL3341313 | 0.75 | HRH3 (0.43) | SYKKMT2AMEN1PDE4DPDE7A | |
| SCHEMBL20442664 | 0.74 | SMN1; SMN2 (0.42) | KMT2AMEN1NPC1SMN1; SMN2KDM1A | |
| SCHEMBL3342117 | 0.74 | PDE4D (0.39) | MKNK1MKNK2SYKNPC1SMN1; SMN2 | |
| SCHEMBL3343187 | 0.72 | P2RX7 (0.47) | MKNK1MKNK2SYKPDK2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100160384-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | ROCHE PALO ALTO LLC | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160384-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | P2RY1, P2RX6, P2RX3 | MKNK1 2405/4885MKNK2 2356/4885NR5A2 655/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.