Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | NR5A2 | O00482 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PI4KA | P42356 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3343786 | 0.81 | MKNK1 (0.39) | SMN1; SMN2ALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL2614654 | 0.80 | ALDH1A1 (0.41) | SMN1; SMN2ALDH1A1KDM4ECYP11B1KMT2A | |
| SCHEMBL3346678 | 0.80 | KEAP1 (0.59) | SMN1; SMN2ALDH1A1KDM4ECYP11B1KMT2A | |
| SCHEMBL3343246 | 0.80 | MEN1 (0.48) | SMN1; SMN2ALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL20442664 | 0.79 | SMN1; SMN2 (0.42) | SMN1; SMN2ALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL3342753 | 0.75 | HDAC3 (0.44) | SMN1; SMN2ALDH1A1KDM4ECYP11B1RAB9A | |
| SCHEMBL3343074 | 0.74 | GAA (0.42) | SMN1; SMN2ALDH1A1KDM4ECYP11B1RAB9A | |
| SCHEMBL5346265 | 0.72 | KMT2A (0.56) | SMN1; SMN2ALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL9384038 | 0.72 | KMT2A (0.55) | SMN1; SMN2ALDH1A1KDM4EKMT2ANPC1 | |
| SCHEMBL4128219 | 0.70 | DYRK1A (0.41) | KMT2APIK3CDPIK3CBPIK3CGMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100160384-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | ROCHE PALO ALTO LLC | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160384-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | P2RY1, P2RX6, P2RX3 | SMN1; SMN2 2819/4885ALDH1A1 1506/4885KDM4E 2591/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.