Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | APEX1 | P27695 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | HTR2B | P41595 | 1/20 | 0.54 |
| ▸ | STAT6 | P42226 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL642859 | 0.86 | ALDH1A1 (0.57) | LMNASMN1; SMN2MAPK1TSHRADRA2A | |
| SCHEMBL8261355 | 0.86 | SMN1; SMN2 (0.59) | LMNASMN1; SMN2MAPK1TSHRADRA2A | |
| SCHEMBL131628 | 0.85 | GAA (0.65) | MAPK1APEX1TSHRADRA2ACYP2D6 | |
| SCHEMBL31079411 | 0.85 | MAPK1 (0.54) | LMNAMAPK1APEX1TSHRALDH1A1 | |
| SCHEMBL30219287 | 0.85 | SMN1; SMN2 (0.57) | LMNASMN1; SMN2MAPK1TSHRADRA2A | |
| SCHEMBL9598030 | 0.85 | SMN1; SMN2 (0.57) | LMNASMN1; SMN2MAPK1TSHRADRA2A | |
| SCHEMBL3220624 | 0.85 | SMN1; SMN2 (0.57) | LMNASMN1; SMN2MAPK1TSHRADRA2A | |
| SCHEMBL1364551 | 0.85 | MAPK1 (0.54) | LMNAMAPK1APEX1TSHRALDH1A1 | |
| SCHEMBL3344597 | 0.85 | SMN1; SMN2 (0.57) | LMNASMN1; SMN2MAPK1TSHRADRA2A | |
| Hydrochloric Acid SCHEMBL10988216 | 0.83 | GAA (0.63) | MAPK1APEX1TSHRADRA2ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3975434-A | Processes of producing 2,5-disubstituted benzamides | SOCIETE D'ETUDES SCIENTIFIQUES ET INDUSTRIELLES DE L'ILE-DE-FRANCE (FR) | 1976-08-17 | — | — | US | claimed |
| US-20240158372-A1 | BISAMIDE SARCOMERE ACTIVATING COMPOUNDS AND USES THEREOF | AMGEN INC. | 2024-05-16 | — | — | US | disclosed |
| CN-117126085-A | Preparation method of N- [2- (diethylamino) ethyl ] -5- (methylsulfonyl) -2-methoxybenzamide salt | 江苏恩华药业股份有限公司 | 2023-11-28 | — | — | CN | disclosed |
| US-11780826-B2 | Bisamide sarcomere activating compounds and uses thereof | AMGEN INC. (US) | 2023-10-10 | — | — | US | disclosed |
| US-20220289685-A1 | ANTIMALARIAL HEXAHYDROPYRIMIDINE ANALOGUES | UCB BIOPHARMA SRL (SOCIETE A RESPONSABILITE LIMITEE) (BE) | 2022-09-15 | — | — | US | disclosed |
| US-20220281850-A1 | BISAMIDE SARCOMERE ACTIVATING COMPOUNDS AND USES THEREOF | AMGEN INC. | 2022-09-08 | — | — | US | disclosed |
| EP-4017591-A1 | ANTIMALARIAL HEXAHYDROPYRIMIDINE ANALOGUES | UCB Biopharma SRL (BE) | 2022-06-29 | — | — | EP | disclosed |
| US-11299479-B1 | Bisamide sarcomere activating compounds and uses thereof | CYTOKINETICS, INC. (US) | 2022-04-12 | — | — | US | disclosed |
| CN-114206856-A | Anti-malarial hexahydropyrimidine analogues | UCB生物制药有限责任公司 | 2022-03-18 | — | — | CN | disclosed |
| US-11254658-B2 | Bisamide sarcomere activating compounds and uses thereof | AMGEN INC. (US) | 2022-02-22 | — | — | US | disclosed |
| WO-1997022604-A1 | NOVEL SUBSTITUTED 4-(1H-BENZIMIDAZOL-2-YL)[1,4]DIAZEPANES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | HOECHST MARION ROUSSEL, INC. (US) | 1997-06-26 | — | — | WO | disclosed |
| WO-1997019074-A1 | SUBSTITUTED 4-(1H-BENZIMIDAZOL-2-YL-AMINO)PIPERIDINES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | HOECHST MARION ROUSSEL, INC. (US) | 1997-05-29 | — | — | WO | disclosed |
| US-4935511-A | Nervous system, gastrointestinal disorders | RORER PHARMACEUTICAL CORPORATION (US) | 1990-06-19 | — | — | US | disclosed |
| US-4673686-A | CNS MODIFIERS, ANTI-APOMORPHINE ANTIENETIC ACITIVTY/ | SOCIETE D'ETUDES SCIENTIFIQUES ET INDUSTRIELLE DE L'ILE DE FRANCE (FR) | 1987-06-16 | — | — | US | disclosed |
| US-4624961-A | LEARNING ENHANCEMENT | A. H. ROBINS COMPANY, INCORPORATED (US) | 1986-11-25 | — | — | US | disclosed |
| US-4352802-A | DESALINATION OF SEA WATER | BEECHAM GROUP LIMITED (GB) | 1982-10-05 | — | — | US | disclosed |
| EP-0041817-A1 | Benzamide derivatives, process for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1981-12-16 | — | — | EP | disclosed |
| US-4197243-A | ANTIPSYCHOTICS, STRONG CNS DEPRESSANTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1980-04-08 | — | — | US | disclosed |
| US-4097487-A | CNS DEPRESSANTS, ANTIPSYCHOTICS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JA) | 1978-06-27 | — | — | US | disclosed |
| US-3975434-A | Processes of producing 2,5-disubstituted benzamides | SOCIETE D'ETUDES SCIENTIFIQUES ET INDUSTRIELLES DE L'ILE-DE-FRANCE (FR) | 1976-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11254658-B2 | Bisamide sarcomere activating compounds and uses thereof | TNNI3, TNNT2, TNNC1 | LMNA 42/4885SMN1; SMN2 126/4885MAPK1 1704/4885 |
| US-11780826-B2 | Bisamide sarcomere activating compounds and uses thereof | TNNI3, TNNT2, TNNC1 | LMNA 42/4885SMN1; SMN2 126/4885MAPK1 1704/4885 |
| US-20240158372-A1 | BISAMIDE SARCOMERE ACTIVATING COMPOUNDS AND USES THEREOF | TNNI3, TNNT2, TNNC1 | LMNA 42/4885SMN1; SMN2 126/4885MAPK1 1704/4885 |
| US-20220289685-A1 | ANTIMALARIAL HEXAHYDROPYRIMIDINE ANALOGUES | G6PD, DPYD, DHFR | LMNA 3982/4885SMN1; SMN2 3408/4885MAPK1 2090/4885 |
| US-20220281850-A1 | BISAMIDE SARCOMERE ACTIVATING COMPOUNDS AND USES THEREOF | TNNI3, TNNT2, TNNC1 | LMNA 42/4885SMN1; SMN2 126/4885MAPK1 1704/4885 |
| US-11299479-B1 | Bisamide sarcomere activating compounds and uses thereof | TNNI3, TNNT2, TNNC1 | LMNA 42/4885SMN1; SMN2 126/4885MAPK1 1704/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.