Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.49 |
| ▸ | MAOB | P27338 | 7/20 | 0.41 |
| ▸ | MAOA | P21397 | 6/20 | 0.41 |
| ▸ | AOC2 | O75106 | 5/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.36 |
| ▸ | PRCP | P42785 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12060988 | 1.00 | HRH3 (0.49) | HRH3MAOBMAOAAOC2DAO | |
| SCHEMBL30142986 | 1.00 | HRH3 (0.49) | HRH3MAOBMAOAAOC2DAO | |
| SCHEMBL1568046 | 0.81 | CA2 (0.41) | HRH3NISCH | |
| SCHEMBL30513665 | 0.81 | CA2 (0.41) | HRH3NISCH | |
| SCHEMBL6028552 | 0.81 | CA2 (0.41) | HRH3NISCH | |
| SCHEMBL9113367 | 0.81 | HRH3 (0.40) | HRH3MAOBMAOAAOC2DAO | |
| SCHEMBL451210 | 0.80 | MAOB (0.41) | HRH3MAOBMAOAAOC2DAO | |
| SCHEMBL434337 | 0.80 | MAOA (0.41) | HRH3MAOBMAOAAOC2DAO | |
| SCHEMBL28842254 | 0.80 | MAOB (0.49) | HRH3MAOBMAOAAOC2DAO | |
| SCHEMBL6209606 | 0.80 | MAOB (0.41) | HRH3MAOBMAOAAOC2DAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8097738-B2 | Ruthenium (II) catalysts for use in stereoselective cyclopropanations | VANDA PHARMACEUTICALS INC. (US) | 2012-01-17 | — | — | US | claimed |
| US-7754902-B2 | Ruthenium(II) catalysts for use in stereoselective cyclopropanations | VANDA PHARMACEUTICALS, INC. (US) | 2010-07-13 | — | — | US | claimed |
| CN-110330982-A | A kind of material of the soil sanitation reparation of adjustable function | 权冉(银川)科技有限公司 | 2019-10-15 | — | — | CN | disclosed |
| CN-106543119-B | Preparation method of optically pure tasimelteon | 浙江工业大学 | 2019-07-26 | — | — | CN | disclosed |
| CN-109748759-A | Water treatment material and soil purifying, repairing and fertilizing material and preparation and use method thereof | 权冉(银川)科技有限公司 | 2019-05-14 | — | — | CN | disclosed |
| US-9822103-B2 | Inhibitors of lysine methyl transferase | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-11-21 | — | — | US | disclosed |
| CN-106543119-A | Preparation method of optically pure tasimelteon | 浙江工业大学 | 2017-03-29 | — | — | CN | disclosed |
| US-20160297805-A1 | INHIBITORS OF LYSINE METHYL TRANSFERASE | BRISTOL MYERS SQUIBB CO (US) | 2016-10-13 | — | — | US | disclosed |
| WO-2015077194-A1 | INHIBITORS OF LYSINE METHYL TRANSFERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-05-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160297805-A1 | INHIBITORS OF LYSINE METHYL TRANSFERASE | EZH2, DOT1L, EHMT1 | HRH3 766/4885MAOB 2894/4885MAOA 2913/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.