Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.55 |
| ▸ | MEN1 | O00255 | 7/20 | 0.55 |
| ▸ | MAPT | P10636 | 7/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.55 |
| ▸ | HPGD | P15428 | 6/20 | 0.55 |
| ▸ | POLB | P06746 | 5/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.55 |
| ▸ | PKM | P14618 | 5/20 | 0.55 |
| ▸ | RECQL | P46063 | 4/20 | 0.55 |
| ▸ | BLM | P54132 | 4/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.55 |
| ▸ | CASP1 | P29466 | 2/20 | 0.55 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.55 |
| ▸ | CASP7 | P55210 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 4/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23954159 | 0.78 | ALDH1A1 (0.52) | KDM4EALDH1A1HSD17B10MEN1MAPT | |
| Iodide SCHEMBL4392302 | 0.77 | RAB9A (0.59) | KDM4EALDH1A1HSD17B10MEN1MAPT | |
| SCHEMBL170196 | 0.76 | RAB9A (0.64) | KDM4EALDH1A1HSD17B10MEN1MAPT | |
| SCHEMBL29374931 | 0.76 | RAB9A (0.64) | KDM4EALDH1A1HSD17B10MEN1MAPT | |
| SCHEMBL29180363 | 0.76 | KDM4E (0.58) | KDM4EALDH1A1HSD17B10MEN1MAPT | |
| SCHEMBL3060017 | 0.74 | KDM4E (0.58) | KDM4EALDH1A1HSD17B10MEN1MAPT | |
| SCHEMBL29746310 | 0.74 | CYP11B1 (0.53) | KDM4EALDH1A1HSD17B10MEN1MAPT | |
| SCHEMBL3647009 | 0.74 | CYP11B1 (0.53) | KDM4EALDH1A1HSD17B10MEN1MAPT | |
| SCHEMBL34463709 | 0.74 | RAB9A (0.61) | KDM4EALDH1A1HSD17B10MEN1MAPT | |
| SCHEMBL10866984 | 0.74 | RAB9A (0.61) | KDM4EALDH1A1HSD17B10MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111471009-A | Preparation method and application of 2-arylquinoline derivative | 安阳师范学院 | 2020-07-31 | — | — | CN | claimed |
| CN-105801478-B | A kind of method that 2- aryl quinolines are prepared by cyclo other compounds | 常州大学 | 2018-05-25 | — | — | CN | claimed |
| JP-61277675-A | — | — | None | — | — | JP | disclosed |
| EP-4330233-A1 | PHENYL -O-QUINOLINE, QUINAZOLINE, THIENOPYRIDINE, THIENOPYRIMIDINE, PYRROLOPYRIDINE, PYRROLOPYRIMIDINE COMPOUNDS HAVING ANTICANCER ACTIVITY | Chengdu Anticancer Bioscience, Ltd. (CN) | 2024-03-06 | — | — | EP | disclosed |
| CN-111471009-A | Preparation method and application of 2-arylquinoline derivative | 安阳师范学院 | 2020-07-31 | — | — | CN | disclosed |
| CN-105801478-B | A kind of method that 2- aryl quinolines are prepared by cyclo other compounds | 常州大学 | 2018-05-25 | — | — | CN | disclosed |
| CN-105801478-A | Method for preparing 2-aryl quinoline by cyclic ether compound | 常州大学 | 2016-07-27 | — | — | CN | disclosed |
| WO-2015106272-A1 | SMALL MOLECULE INHIBITORS OF APOBEC3G AND APOBEC3B | HARKI DANIEL A (US) | 2015-07-16 | — | — | WO | disclosed |
| WO-2015040424-A1 | TETRAHYDROISOQUINOLINE COMPOUNDS AND THEIR USE AS PYRUVATE DEHYDROGENASE KINASE INHIBITORS | VERNALIS (R&D) LIMITED (GB) | 2015-03-26 | — | — | WO | disclosed |
| WO-2008154207-A9 | METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS | THE BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-04-22 | — | — | WO | disclosed |
| US-20090118135-A1 | METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS | THE BURNHAM INSTITUTE (US) | 2009-05-07 | — | — | US | disclosed |
| US-20090069301-A1 | Acridine and Quinoline Derivatives as Sirtuin Modulators | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-03-12 | — | — | US | disclosed |
| WO-2008154207-A1 | METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS | THE BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2008-12-18 | — | — | WO | disclosed |
| EP-1856099-A2 | ACRIDINE AND QUINOLINE DERIVATIVES AS SIRTUIN MODULATORS | Sirtris Pharmaceuticals, Inc. (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006094237-A2 | ACRIDINE AND QUINOLINE DERVATIVES AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2006-09-08 | — | — | WO | disclosed |
| JP-S61277675-A | 2-QUINOYLFURAN DERIVATIVE | MITSUI PETROCHEM IND LTD | 1986-12-08 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118135-A1 | METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS | BCL2, BAX, BAD | KDM4E 3373/4885ALDH1A1 3724/4885HSD17B10 2065/4885 |
| US-20090069301-A1 | Acridine and Quinoline Derivatives as Sirtuin Modulators | SIRT1, SIRT3, SIRT2 | KDM4E 2555/4885ALDH1A1 1461/4885HSD17B10 3123/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.