Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 3/20 | 0.39 |
| ▸ | HTR2C | P28335 | 3/20 | 0.39 |
| ▸ | HTR2B | P41595 | 3/20 | 0.39 |
| ▸ | FABP4 | P15090 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | EDNRB | P24530 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3350444 | 0.85 | SMN1; SMN2 (0.58) | LMNASMN1; SMN2TSHRPOLBFABP4 | |
| SCHEMBL2313628 | 0.84 | HTR2A (0.36) | LMNASMN1; SMN2TSHRPOLBHTR2A | |
| SCHEMBL2312288 | 0.82 | L3MBTL1 (0.51) | LMNASMN1; SMN2TSHRGAAHSD17B10 | |
| SCHEMBL1365646 | 0.81 | PPARG (0.44) | SMN1; SMN2TSHRMEN1KMT2AATM | |
| SCHEMBL2834290 | 0.74 | MEN1 (0.49) | LMNATSHRGAAMEN1KMT2A | |
| SCHEMBL31502941 | 0.72 | MAPK8 (0.56) | LMNASMN1; SMN2TSHRGAAPOLB | |
| SCHEMBL2837392 | 0.72 | MEN1 (0.42) | LMNASMN1; SMN2TSHRHSD17B10POLB | |
| SCHEMBL2830643 | 0.72 | TDP1 (0.62) | LMNASMN1; SMN2HSD17B10MEN1KMT2A | |
| SCHEMBL2832448 | 0.72 | RAB9A (0.49) | LMNASMN1; SMN2TSHRHSD17B10POLB | |
| SCHEMBL2832378 | 0.72 | MEN1 (0.49) | LMNASMN1; SMN2TSHRGAAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8415373-B2 | Isoquinolinone derivatives as NK3 antagonists | H. LUNDBECK A/S (DK) | 2013-04-09 | — | — | US | claimed |
| WO-2010045948-A1 | ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS | H. LUNDBECK A/S (DK) | 2010-04-29 | — | — | WO | claimed |
| US-8415373-B2 | Isoquinolinone derivatives as NK3 antagonists | H. LUNDBECK A/S (DK) | 2013-04-09 | — | — | US | disclosed |
| WO-2010045948-A1 | ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS | H. LUNDBECK A/S (DK) | 2010-04-29 | — | — | WO | disclosed |