Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3344869 | 0.82 | LMNA (0.43) | TSHRMEN1KMT2APOLBGAA | |
| SCHEMBL1365646 | 0.78 | PPARG (0.44) | TSHRMEN1KMT2ASMN1; SMN2MAPK1 | |
| SCHEMBL2313394 | 0.75 | L3MBTL1 (0.54) | L3MBTL1TDP1TSHRMEN1KMT2A | |
| SCHEMBL2149158 | 0.72 | L3MBTL1 (0.51) | L3MBTL1TDP1TSHRMEN1KMT2A | |
| SCHEMBL3350444 | 0.71 | SMN1; SMN2 (0.58) | TSHRMEN1KMT2APOLBKDM4E | |
| SCHEMBL2313628 | 0.68 | HTR2A (0.36) | L3MBTL1TSHRMEN1KMT2APOLB | |
| SCHEMBL1366629 | 0.67 | PPARG (0.52) | TSHRMEN1KMT2ASMN1; SMN2MAPK1 | |
| SCHEMBL15969988 | 0.66 | L3MBTL1 (0.83) | L3MBTL1TDP1MEN1KMT2AKDM4E | |
| SCHEMBL164622 | 0.63 | L3MBTL1 (0.72) | L3MBTL1TSHRKMT2APOLBGAA | |
| SCHEMBL1940351 | 0.63 | PTGDR2 (0.75) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2350015-A1 | ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS | H. Lundbeck A/S (DK) | 2011-08-03 | — | — | EP | claimed |