SCHEMBL3344914

SCHEMBL3344914

CC(Cc1cc2c(N)nc(-c3cnccn3)nc2s1)c1ccccn1

nearest known ligand 0.64

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 18/20 0.64
ADORA1 P30542 17/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3350946 0.82 ADORA2A (0.64) ADORA2AADORA1
SCHEMBL3344910 0.82 ADORA2A (0.57) ADORA2AADORA1
SCHEMBL3344541 0.81 ADORA2A (0.63) ADORA2AADORA1
SCHEMBL3348936 0.80 ADORA2A (0.64) ADORA2AADORA1
SCHEMBL3304186 0.78 ADORA2A (1.00) ADORA2AADORA1
SCHEMBL3305685 0.75 ADORA2A (0.73) ADORA2AADORA1
SCHEMBL3302953 0.74 ADORA2A (0.57) ADORA2AADORA1
SCHEMBL3302454 0.69 ADORA2A (0.67) ADORA2AADORA1
SCHEMBL13389918 0.67 ADORA2A (0.57) ADORA2AADORA1
Hydrochloric Acid SCHEMBL3301284 0.66 ADORA2A (0.56) ADORA2AADORA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010045015-A1 HETEROARYL SUBSTITUTED THIENO[2,3-D]PYRIMIDINE AND THEIR USE AS ADENOSINE A2A RECEPTOR ANTAGONISTS JANSSEN PHARMACEUTICA NV (BE) 2010-04-22 WO disclosed