SCHEMBL3345522

SCHEMBL3345522

O=C(NCCc1cccc(Br)c1)C1CC1

nearest known ligand 0.55

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 1/20 0.53
NPC1 O15118 1/20 0.52
RAB9A P51151 1/20 0.52
TAAR1 Q96RJ0 4/20 0.51
GLA P06280 1/20 0.51
LMNA P02545 1/20 0.49
TP53 P04637 1/20 0.49
MEN1 O00255 1/20 0.49
POLB P06746 1/20 0.49
KMT2A Q03164 1/20 0.49
CYP2C19 P33261 1/20 0.49
ALDH1A1 P00352 1/20 0.48
TSHR P16473 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
GAA P10253 1/20 0.48
KDM4E B2RXH2 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL552941 0.93 ALDH1A1 (0.54) CNR1NPC1RAB9ATAAR1GLA
SCHEMBL3225765 0.85 ALDH1A1 (0.58) NPC1RAB9ATP53POLBKMT2A
SCHEMBL2178711 0.81 ALDH1A1 (0.52) MEN1POLBKMT2ACYP2C19ALDH1A1
SCHEMBL23417495 0.81 CYP2C19 (0.68) TAAR1LMNAMEN1POLBKMT2A
SCHEMBL901955 0.80 NPC1 (0.63) CNR1NPC1RAB9ATAAR1MEN1
SCHEMBL17048526 0.79 ALDH1A1 (0.63) NPC1RAB9ATP53MEN1POLB
SCHEMBL31173308 0.79 MTNR1A (0.67) CNR1NPC1RAB9ATAAR1GAA
SCHEMBL1010819 0.78 TAAR1 (0.62) CNR1NPC1RAB9ATAAR1LMNA
SCHEMBL20368746 0.78 SPR (0.53) TAAR1GLALMNAPOLBKMT2A
SCHEMBL7272444 0.77 TAAR1 (0.64) TAAR1LMNAMEN1POLBKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010044054-A1 PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES ACTELION PHARMACEUTICALS LTD (CH) 2010-04-22 WO claimed
CN-115141197-B 3-aromatic heterocycle substituted phenyl derivative and preparation method and application thereof 安徽医科大学 2024-03-26 CN disclosed
CN-115141197-A 3-aromatic heterocyclic substituted phenyl derivative and preparation method and application thereof 安徽医科大学 2022-10-04 CN disclosed
WO-2010044054-A1 PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES ACTELION PHARMACEUTICALS LTD (CH) 2010-04-22 WO disclosed