Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | LMNA | P02545 | 6/20 | 0.49 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 9/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | PRKDC | P78527 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3349400 | 0.84 | SIRT6 (0.58) | ALDH1A1LMNASIRT6MAPTKDM4E | |
| SCHEMBL3316503 | 0.78 | ALDH1A1 (0.51) | ALDH1A1LMNASIRT6MAPTPOLB | |
| SCHEMBL3316500 | 0.78 | ALDH1A1 (0.51) | ALDH1A1LMNASIRT6MAPTPOLB | |
| SCHEMBL3316506 | 0.78 | ALDH1A1 (0.51) | ALDH1A1LMNASIRT6MAPTPOLB | |
| SCHEMBL3315996 | 0.75 | ALDH1A1 (0.53) | ALDH1A1LMNASIRT6MAPTPOLB | |
| SCHEMBL3316004 | 0.75 | ALDH1A1 (0.53) | ALDH1A1LMNASIRT6MAPTPOLB | |
| SCHEMBL3316000 | 0.75 | ALDH1A1 (0.53) | ALDH1A1LMNASIRT6MAPTPOLB | |
| SCHEMBL15994800 | 0.74 | SIRT6 (0.69) | ALDH1A1LMNASIRT6MAPTKDM4E | |
| SCHEMBL3310207 | 0.71 | SIRT6 (0.61) | ALDH1A1LMNASIRT6MAPTRAB9A | |
| SCHEMBL3310202 | 0.71 | SIRT6 (0.61) | ALDH1A1LMNASIRT6MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010049731-A1 | PYRAZOLO- AND IMIDAZOPYRIDINYLPYRIMIDINEAMINES AS IGF-1R TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-05-06 | — | — | WO | disclosed |