Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3316500 | 1.00 | ALDH1A1 (0.51) | ALDH1A1LMNASIRT6MAPTKMT2A | |
| SCHEMBL3316506 | 1.00 | ALDH1A1 (0.51) | ALDH1A1LMNASIRT6MAPTKMT2A | |
| SCHEMBL3319515 | 0.83 | SIRT6 (0.60) | ALDH1A1LMNASIRT6MAPTKMT2A | |
| SCHEMBL3313704 | 0.79 | ALDH1A1 (0.60) | ALDH1A1LMNASIRT6MAPTKMT2A | |
| SCHEMBL3551116 | 0.78 | MMP2 (0.42) | ALDH1A1SIRT6MAPTKMT2AMEN1 | |
| SCHEMBL3345704 | 0.78 | ALDH1A1 (0.49) | ALDH1A1LMNASIRT6MAPTKMT2A | |
| SCHEMBL3316004 | 0.77 | ALDH1A1 (0.53) | ALDH1A1LMNASIRT6MAPTKMT2A | |
| SCHEMBL3316000 | 0.77 | ALDH1A1 (0.53) | ALDH1A1LMNASIRT6MAPTKMT2A | |
| SCHEMBL3315996 | 0.77 | ALDH1A1 (0.53) | ALDH1A1LMNASIRT6MAPTKMT2A | |
| SCHEMBL18035084 | 0.76 | ALDH1A1 (0.48) | ALDH1A1LMNASIRT6MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100105655-A1 | NOVEL COMPOUNDS 515 | ASTRAZENECA AB | 2010-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105655-A1 | NOVEL COMPOUNDS 515 | TYMS, ABCG2, UMPS | ALDH1A1 649/4885LMNA 3341/4885SIRT6 1324/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.