Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | FLT1 | P17948 | 1/20 | 0.49 |
| ▸ | FLT4 | P35916 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1951610 | 0.86 | DGAT1 (0.51) | DGAT1ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL24671489 | 0.86 | NPC1 (0.50) | DGAT1ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6415801 | 0.83 | ALDH1A1 (0.58) | ALDH1A1NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL3341029 | 0.83 | SMN1; SMN2 (0.50) | DGAT1ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29278885 | 0.82 | NPC1 (0.50) | DGAT1ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29278887 | 0.82 | NPC1 (0.50) | DGAT1ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12121133 | 0.81 | ALDH1A1 (0.47) | ALDH1A1NPC1LMNAGAAPOLB | |
| SCHEMBL26905965 | 0.81 | HTT (0.54) | ALDH1A1NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL20460550 | 0.81 | HTT (0.54) | ALDH1A1NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL403566 | 0.81 | KMT2A (0.46) | DGAT1ALDH1A1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11214573-B2 | Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors | INCYTE HOLDINGS CORPORATION (US) | 2022-01-04 | — | — | US | disclosed |
| US-20200181077-A1 | CYCLOPROPYLAMINES AS LSD1 INHIBITORS | INCYTE CORPORATION (US) | 2020-06-11 | — | — | US | disclosed |
| US-20200079783-A1 | AZETIDINYL PHENYL, PYRIDYL OR PYRAZINYL CARBOXAMIDE DERIVATIVES AS JAK INHIBITORS | INCYTE CORPORATION | 2020-03-12 | — | — | US | disclosed |
| US-10513522-B2 | Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors | INCYTE CORPORATION (US) | 2019-12-24 | — | — | US | disclosed |
| US-20170253598-A1 | AZETIDINYL PHENYL, PYRIDYL OR PYRAZINYL CARBOXAMIDE DERIVATIVES AS JAK INHIBITORS | INCYTE CORPORATION | 2017-09-07 | — | — | US | disclosed |
| US-9695175-B2 | Highly selective c-Met inhibitors as anticancer agents | CB THERAPEUTICS INC. (KY) | 2017-07-04 | — | — | US | disclosed |
| US-9695175-B2 | Highly selective c-Met inhibitors as anticancer agents | CB THERAPEUTICS INC. (KY) | 2017-07-04 | — | — | US | disclosed |
| US-20170158633-A1 | CYCLOPROPYLAMINES AS LSD1 INHIBITORS | INCYTE CORPORATION (US) | 2017-06-08 | — | — | US | disclosed |
| US-9611269-B2 | Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors | INCYTE CORPORATION (US) | 2017-04-04 | — | — | US | disclosed |
| US-9527835-B2 | Cyclopropylamines as LSD1 inhibitors | INCYTE CORPORATION (US) | 2016-12-27 | — | — | US | disclosed |
| US-20130018034-A1 | AZETIDINYL PHENYL, PYRIDYL OR PYRAZINYL CARBOXAMIDE DERIVATIVES AS JAK INHIBITORS | INCYTE CORPORATION (US) | 2013-01-17 | — | — | US | disclosed |
| WO-2012177606-A1 | AZETIDINYL PHENYL, PYRIDYL OR PYRAZINYL CARBOXAMIDE DERIVATIVES AS JAK INHIBITORS | INCYTE CORPORATION (US) | 2012-12-27 | — | — | WO | disclosed |
| EP-1784388-B3 | BIPHENYLOXYACETIC ACID DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASE | ASTRAZENECA AB (SE) | 2012-09-05 | — | — | EP | disclosed |
| US-20120178732-A1 | Biphenyloxyacetic Acid Derivatives for the Treatment of Respiratory Disease | LUKER TIMOTHY JON (GB) | 2012-07-12 | — | — | US | disclosed |
| CN-101048369-B | Biphenyloxyacetic acid derivatives for the treatment of respiratory disease | ASTRAZENECA AB | 2010-09-08 | — | — | CN | disclosed |
| US-20100160285-A1 | Biphenyloxyacetic Acid Derivatives for the Treatment of Respiratory Disease | ASTRAZENECA AB (SE) | 2010-06-24 | — | — | US | disclosed |
| US-7737135-B2 | Biphenyloxyacetic acid derivatives for the treatment of respiratory disease | ASTRAZENECA AB (SE) | 2010-06-15 | — | — | US | disclosed |
| EP-1784388-B1 | BIPHENYLOXYACETIC ACID DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASE | ASTRAZENECA AB (SE) | 2009-11-04 | — | — | EP | disclosed |
| US-20080132480-A1 | Biphenyloxyacetic Acid Derivatives for the Treatment of Respiratory Disease | ASTRAZENECA AB (SE) | 2008-06-05 | — | — | US | disclosed |
| CN-101048369-A | Biphenyloxyacetic acid derivatives for the treatment of respiratory disease | ASTRAZENECA AB (SE) | 2007-10-03 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178732-A1 | Biphenyloxyacetic Acid Derivatives for the Treatment of Respiratory Disease | CYP26A1, CYP1A1, GPBAR1 | DGAT1 1488/4885ALDH1A1 42/4885NPC1 1236/4885 |
| US-10513522-B2 | Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors | JAK1, JAK3, JAK2 | DGAT1 3797/4885ALDH1A1 3252/4885NPC1 4373/4885 |
| US-20100160285-A1 | Biphenyloxyacetic Acid Derivatives for the Treatment of Respiratory Disease | CYP26A1, CYP1A1, GPBAR1 | DGAT1 1488/4885ALDH1A1 42/4885NPC1 1236/4885 |
| US-20130018034-A1 | AZETIDINYL PHENYL, PYRIDYL OR PYRAZINYL CARBOXAMIDE DERIVATIVES AS JAK INHIBITORS | JAK1, JAK3, JAK2 | DGAT1 3797/4885ALDH1A1 3252/4885NPC1 4373/4885 |
| US-20080132480-A1 | Biphenyloxyacetic Acid Derivatives for the Treatment of Respiratory Disease | CYP26A1, CYP1A1, GPBAR1 | DGAT1 1488/4885ALDH1A1 42/4885NPC1 1236/4885 |
| US-20200181077-A1 | CYCLOPROPYLAMINES AS LSD1 INHIBITORS | KDM1B, KDM1A, KDM2A | DGAT1 1497/4885ALDH1A1 457/4885NPC1 1387/4885 |
| US-11214573-B2 | Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors | JAK1, JAK3, JAK2 | DGAT1 3797/4885ALDH1A1 3252/4885NPC1 4373/4885 |
| US-20170253598-A1 | AZETIDINYL PHENYL, PYRIDYL OR PYRAZINYL CARBOXAMIDE DERIVATIVES AS JAK INHIBITORS | JAK1, JAK3, JAK2 | DGAT1 3797/4885ALDH1A1 3252/4885NPC1 4373/4885 |
| US-20200079783-A1 | AZETIDINYL PHENYL, PYRIDYL OR PYRAZINYL CARBOXAMIDE DERIVATIVES AS JAK INHIBITORS | JAK1, JAK3, JAK2 | DGAT1 3797/4885ALDH1A1 3252/4885NPC1 4373/4885 |
| US-20170158633-A1 | CYCLOPROPYLAMINES AS LSD1 INHIBITORS | KDM1B, KDM1A, KDM2A | DGAT1 1497/4885ALDH1A1 457/4885NPC1 1387/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.