Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 18/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 18/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3350904 | 0.87 | HCRTR1 (0.51) | HCRTR1HCRTR2GRIN2B | |
| SCHEMBL3345948 | 0.84 | HCRTR2 (0.38) | HCRTR1HCRTR2MEN1ALDH1A1MAPK1 | |
| SCHEMBL2056953 | 0.79 | KCNA5 (0.39) | HCRTR1HCRTR2MEN1ALDH1A1MAPK1 | |
| SCHEMBL3350496 | 0.77 | HCRTR1 (0.43) | HCRTR1HCRTR2MEN1ALDH1A1MAPK1 | |
| SCHEMBL3350773 | 0.77 | HCRTR1 (0.49) | HCRTR1HCRTR2 | |
| SCHEMBL2635182 | 0.74 | HCRTR1 (0.38) | HCRTR1HCRTR2MEN1ALDH1A1MAPK1 | |
| SCHEMBL3350896 | 0.71 | HCRTR1 (0.51) | HCRTR1HCRTR2GRIN2B | |
| SCHEMBL2635826 | 0.71 | PDE10A (0.39) | HCRTR1HCRTR2GRIN2B | |
| SCHEMBL984761 | 0.69 | MCL1 (0.46) | MEN1ALDH1A1MAPK1KMT2A | |
| SCHEMBL3344320 | 0.68 | HCRTR1 (0.47) | HCRTR1HCRTR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010038200-A1 | OXAZOLIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2010-04-08 | — | — | WO | claimed |
| WO-2010038200-A1 | OXAZOLIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2010-04-08 | — | — | WO | disclosed |