Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 8/20 | 0.51 |
| ▸ | HCRTR2 | O43614 | 8/20 | 0.51 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3345948 | 0.86 | HCRTR2 (0.38) | HCRTR1HCRTR2PDE10AGRIN2B | |
| SCHEMBL3350904 | 0.84 | HCRTR1 (0.51) | HCRTR1HCRTR2PDE10AGRIN2B | |
| SCHEMBL3344465 | 0.80 | HCRTR1 (0.51) | HCRTR1HCRTR2 | |
| SCHEMBL2635740 | 0.79 | HCRTR1 (0.51) | HCRTR1HCRTR2PDE10ARIPK2TLR8 | |
| SCHEMBL2056990 | 0.74 | HCRTR1 (0.51) | HCRTR1HCRTR2PDE10AGRIN2B | |
| SCHEMBL2057011 | 0.73 | KMO (0.52) | HCRTR1HCRTR2KMOKDM5AKDM4C | |
| SCHEMBL3344316 | 0.72 | HCRTR1 (0.46) | HCRTR1HCRTR2 | |
| SCHEMBL3345952 | 0.71 | HCRTR1 (0.38) | HCRTR1HCRTR2GRIN2B | |
| SCHEMBL3348002 | 0.68 | HCRTR1 (0.44) | HCRTR1HCRTR2 | |
| SCHEMBL3344362 | 0.67 | HCRTR1 (0.53) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010038200-A1 | OXAZOLIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2010-04-08 | — | — | WO | claimed |
| WO-2010038200-A1 | OXAZOLIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2010-04-08 | — | — | WO | disclosed |