Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 4/20 | 0.50 |
| ▸ | OGA | O60502 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | KIT | P10721 | 1/20 | 0.30 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.30 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.30 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.30 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346205 | 0.93 | OGA (0.53) | GRM5OGACYP1A2DYRK1ATGFBR1 | |
| SCHEMBL3347143 | 0.73 | OGA (0.39) | GRM5OGADYRK1ATGFBR1 | |
| SCHEMBL3346766 | 0.72 | GRM5 (0.53) | GRM5CYP1A2TGFBR1NPC1RAB9A | |
| SCHEMBL3346384 | 0.71 | GRM5 (0.43) | GRM5OGACYP1A2KCNH2DYRK1A | |
| SCHEMBL3347789 | 0.70 | GRM5 (0.49) | GRM5OGACYP1A2DYRK1ATGFBR1 | |
| SCHEMBL2717282 | 0.70 | DYRK1A (0.44) | OGADYRK1ATGFBR1SCN5A | |
| SCHEMBL2177472 | 0.70 | DYRK1A (0.44) | OGACYP1A2DYRK1ATGFBR1SCN5A | |
| SCHEMBL15719787 | 0.70 | DYRK1A (0.44) | OGADYRK1ATGFBR1SCN5ANAMPT | |
| SCHEMBL3346192 | 0.70 | GRM5 (0.47) | GRM5OGADYRK1ATGFBR1SCN5A | |
| SCHEMBL3346711 | 0.69 | GRM5 (0.52) | GRM5OGACYP1A2DYRK1ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | claimed |
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |