Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.35 |
| ▸ | EGLN2 | Q96KS0 | 3/20 | 0.33 |
| ▸ | OGA | O60502 | 1/20 | 0.33 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15719787 | 0.81 | DYRK1A (0.44) | DYRK1ASCN5ATGFBR1OGAPCSK9 | |
| SCHEMBL2717282 | 0.81 | DYRK1A (0.44) | DYRK1ASCN5ATGFBR1OGAPCSK9 | |
| SCHEMBL3347208 | 0.81 | DYRK1A (0.36) | DYRK1ASCN5ATGFBR1OGACDK2 | |
| SCHEMBL3347261 | 0.78 | GRM5 (0.47) | — | |
| SCHEMBL3347519 | 0.75 | GRM4 (0.46) | DYRK1ACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL3347789 | 0.74 | GRM5 (0.49) | DYRK1ASCN5ATGFBR1OGACYP1A2 | |
| SCHEMBL3347027 | 0.74 | GRM5 (0.50) | DYRK1ATGFBR1CYP1A2 | |
| SCHEMBL3346876 | 0.73 | CYP19A1 (0.42) | ALDH1A1 | |
| SCHEMBL2066709 | 0.73 | EGLN2 (0.33) | EGLN2SOS2 | |
| SCHEMBL3346205 | 0.73 | OGA (0.53) | DYRK1ASCN5ATGFBR1OGACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024108957-A1 | 5-CYANOPYRAZOLO[1,5-A]PYRIMIDINE COMPOUND AND SYNTHESIS METHOD THEREFOR | 皖西学院 | 2024-05-30 | — | — | WO | claimed |
| CN-118063466-A | 5-Cyano pyrazolo [1,5-a ] pyrimidine compound and synthetic method thereof | 皖西学院 | 2024-05-24 | — | — | CN | claimed |
| US-20070197510-A1 | Nitriles and medicinal compositions containing the same as the active ingredient | ONO PHARMACEUTICAL CO., LTD. (JP) | 2007-08-23 | — | — | US | claimed |
| EP-1724264-A1 | NITRILES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2006-11-22 | — | — | EP | claimed |
| US-20250099462-A1 | Certain Triazolopyridines and Triazolopyrazines, Compositions Thereof and Methods of Use Therefor | HUTCHISON MEDIPHARMA LTD (CN) | 2025-03-27 | — | — | US | disclosed |
| WO-2024108957-A1 | 5-CYANOPYRAZOLO[1,5-A]PYRIMIDINE COMPOUND AND SYNTHESIS METHOD THEREFOR | 皖西学院 | 2024-05-30 | — | — | WO | disclosed |
| WO-2024108957-A1 | 5-CYANOPYRAZOLO[1,5-A]PYRIMIDINE COMPOUND AND SYNTHESIS METHOD THEREFOR | 皖西学院 | 2024-05-30 | — | — | WO | disclosed |
| WO-2024108957-A1 | 5-CYANOPYRAZOLO[1,5-A]PYRIMIDINE COMPOUND AND SYNTHESIS METHOD THEREFOR | 皖西学院 | 2024-05-30 | — | — | WO | disclosed |
| CN-118063466-A | 5-Cyano pyrazolo [1,5-a ] pyrimidine compound and synthetic method thereof | 皖西学院 | 2024-05-24 | — | — | CN | disclosed |
| CN-118063466-A | 5-Cyano pyrazolo [1,5-a ] pyrimidine compound and synthetic method thereof | 皖西学院 | 2024-05-24 | — | — | CN | disclosed |
| CN-118063466-A | 5-Cyano pyrazolo [1,5-a ] pyrimidine compound and synthetic method thereof | 皖西学院 | 2024-05-24 | — | — | CN | disclosed |
| US-20240139182-A1 | Certain Triazolopyridines and Triazolopyrazines, Compositions Thereof and Methods of Use Therefor | HUTCHISON MEDIPHARMA LTD (CN) | 2024-05-02 | — | — | US | disclosed |
| US-20120245178-A1 | CERTAIN TRIAZOLOPYRIDINES AND TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR | HUTCHISON MEDIPHARMA LIMITED (CN) | 2012-09-27 | — | — | US | disclosed |
| WO-2011079804-A1 | CERTAIN TRIAZOLOPYRIDINES AND TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-07-07 | — | — | WO | disclosed |
| WO-2011079804-A1 | CERTAIN TRIAZOLOPYRIDINES AND TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-07-07 | — | — | WO | disclosed |
| US-20070232586-A1 | Hydrazino-Substituted Heterocyclic Nitrile Compounds and Use Thereof | OHMOTO KAZUYUKI | 2007-10-04 | — | — | US | disclosed |
| US-20070232586-A1 | Hydrazino-Substituted Heterocyclic Nitrile Compounds and Use Thereof | OHMOTO KAZUYUKI | 2007-10-04 | — | — | US | disclosed |
| US-20070197510-A1 | Nitriles and medicinal compositions containing the same as the active ingredient | ONO PHARMACEUTICAL CO., LTD. (JP) | 2007-08-23 | — | — | US | disclosed |
| EP-1739081-A1 | HYDRAZINO-SUBSTITUTED HETEROCYCLIC NITRILE COMPOUNDS AND USE THEREOF | ONO PHARMACEUTICAL CO., LTD. (JP) | 2007-01-03 | — | — | EP | disclosed |
| EP-1724264-A1 | NITRILES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2006-11-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120245178-A1 | CERTAIN TRIAZOLOPYRIDINES AND TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR | KCNJ11, NISCH, CYP4Z1 | DYRK1A 3409/4885SCN5A 865/4885TGFBR1 4422/4885 |
| US-20070197510-A1 | Nitriles and medicinal compositions containing the same as the active ingredient | CTRL, NOS1, CPN1 | DYRK1A 4606/4885SCN5A 737/4885TGFBR1 1980/4885 |
| US-20070232586-A1 | Hydrazino-Substituted Heterocyclic Nitrile Compounds and Use Thereof | CTRL, PRSS1, CTSZ | DYRK1A 4159/4885SCN5A 1352/4885TGFBR1 1318/4885 |
| US-20250099462-A1 | Certain Triazolopyridines and Triazolopyrazines, Compositions Thereof and Methods of Use Therefor | KCNJ11, NISCH, CYP4Z1 | DYRK1A 3409/4885SCN5A 865/4885TGFBR1 4422/4885 |
| US-20240139182-A1 | Certain Triazolopyridines and Triazolopyrazines, Compositions Thereof and Methods of Use Therefor | KCNJ11, NISCH, CYP4Z1 | DYRK1A 3409/4885SCN5A 865/4885TGFBR1 4422/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.