Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 11/20 | 0.47 |
| ▸ | OGA | O60502 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.34 |
| ▸ | GABRE | P78334 | 1/20 | 0.34 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.34 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.34 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.34 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346833 | 0.82 | GRM5 (0.50) | GRM5OGADYRK1ATGFBR1KIT | |
| SCHEMBL3347208 | 0.82 | DYRK1A (0.36) | GRM5OGADYRK1ATGFBR1TSHR | |
| SCHEMBL3345917 | 0.82 | GRM5 (0.44) | GRM5OGADYRK1ATGFBR1SCN5A | |
| SCHEMBL3346819 | 0.79 | SCN5A (0.39) | GRM5OGADYRK1ATGFBR1TSHR | |
| SCHEMBL3346766 | 0.79 | GRM5 (0.53) | GRM5TGFBR1PDE10A | |
| SCHEMBL3347519 | 0.78 | GRM4 (0.46) | GRM5DYRK1A | |
| SCHEMBL3346384 | 0.78 | GRM5 (0.43) | GRM5OGADYRK1ATGFBR1PDE10A | |
| SCHEMBL3348828 | 0.77 | TGFBR1 (0.39) | GRM5OGADYRK1ATGFBR1SCN5A | |
| SCHEMBL3347027 | 0.77 | GRM5 (0.50) | GRM5DYRK1ATGFBR1 | |
| SCHEMBL3346984 | 0.77 | DYRK1A (0.41) | GRM5DYRK1ATGFBR1SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | claimed |
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |