Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.57 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | MC4R | P32245 | 2/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346236 | 0.87 | MC4R (0.65) | KCNH2TAAR1MC4RPOLB | |
| SCHEMBL3346386 | 0.86 | TAAR1 (0.48) | KCNH2TAAR1ALDH1A1GLAMC4R | |
| SCHEMBL3350871 | 0.86 | KCNH2 (0.57) | KCNH2TAAR1ALDH1A1GLAMC4R | |
| SCHEMBL3346496 | 0.85 | KCNH2 (0.56) | KCNH2MC4RCNR1KDM4EKMT2A | |
| SCHEMBL3353041 | 0.82 | CNR1 (0.55) | KCNH2TAAR1ALDH1A1GLAMC4R | |
| SCHEMBL3348171 | 0.82 | TAAR1 (0.53) | KCNH2TAAR1ALDH1A1GLAMC4R | |
| SCHEMBL3346679 | 0.81 | MC4R (0.59) | KCNH2TAAR1ALDH1A1GLAMC4R | |
| SCHEMBL3346376 | 0.80 | MC4R (0.63) | KCNH2TAAR1ALDH1A1GLAMC4R | |
| SCHEMBL3350690 | 0.79 | KCNH2 (0.55) | KCNH2MC4RCNR1ROCK2 | |
| SCHEMBL3350446 | 0.79 | KCNH2 (0.79) | KCNH2ALDH1A1MC4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | claimed |