Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 5/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346464 | 1.00 | MGLL (0.45) | MGLLFFAR4LMNAMAPTSMN1; SMN2 | |
| SCHEMBL2425394 | 0.83 | MGLL (0.48) | MGLLLMNAMAPTSMN1; SMN2NPC1 | |
| SCHEMBL3346286 | 0.82 | MGLL (0.51) | MGLLFFAR4 | |
| SCHEMBL3350922 | 0.82 | MGLL (0.51) | MGLLFFAR4 | |
| SCHEMBL3346282 | 0.82 | MGLL (0.51) | MGLLFFAR4 | |
| SCHEMBL18446074 | 0.82 | MGLL (0.50) | MGLL | |
| SCHEMBL3350643 | 0.81 | MGLL (0.51) | MGLLOPRM1OPRD1OPRK1 | |
| SCHEMBL3346380 | 0.81 | MGLL (0.51) | MGLLOPRM1OPRD1OPRK1 | |
| SCHEMBL3346378 | 0.81 | MGLL (0.51) | MGLLOPRM1OPRD1OPRK1 | |
| SCHEMBL3345924 | 0.79 | MGLL (0.41) | MGLLFFAR4NPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010058318-A1 | 1-OXA-8-AZASPIRO [4, 5 ] DECANE- 8 -CARBOXAMIDE COMPOUNDS AS FAAH INHIBITORS | PFIZER INC. (US) | 2010-05-27 | — | — | WO | disclosed |