Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 5/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | ESRRG | P62508 | 2/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.45 |
| ▸ | TLR2 | O60603 | 1/20 | 0.44 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346236 | 0.89 | MC4R (0.65) | MC4RTAAR1KCNH2POLBGAA | |
| SCHEMBL3346234 | 0.88 | MC4R (0.71) | MC4RTAAR1KCNH2POLBGAA | |
| SCHEMBL3346376 | 0.85 | MC4R (0.63) | MC4RNPC1RAB9ATAAR1KCNH2 | |
| SCHEMBL3353035 | 0.81 | MC4R (0.56) | MC4RTAAR1KCNH2POLBGAA | |
| SCHEMBL3348167 | 0.81 | MC4R (0.60) | MC4RTAAR1KCNH2POLBGAA | |
| SCHEMBL22178742 | 0.80 | MC4R (0.88) | MC4RTAAR1POLBGAA | |
| SCHEMBL3353142 | 0.79 | MC4R (0.62) | MC4RTAAR1POLBGAATLR2 | |
| Hydrochloric Acid SCHEMBL22160650 | 0.79 | MC4R (0.86) | MC4RTAAR1POLBGAA | |
| SCHEMBL3410126 | 0.78 | MC4R (0.57) | MC4RNPC1RAB9ATAAR1KCNH2 | |
| SCHEMBL3348194 | 0.78 | KCNH2 (0.63) | MC4RTAAR1KCNH2POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | claimed |