Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 4/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346236 | 0.86 | MC4R (0.65) | MC4RKCNH2LTA4HEPHX2TAAR1 | |
| SCHEMBL3346234 | 0.85 | MC4R (0.71) | MC4RKCNH2TAAR1POLBGAA | |
| SCHEMBL3346376 | 0.82 | MC4R (0.63) | MC4RKCNH2TAAR1POLBGAA | |
| SCHEMBL3346487 | 0.81 | MC4R (0.59) | MC4RKCNH2TAAR1POLBGAA | |
| SCHEMBL3348167 | 0.80 | MC4R (0.60) | MC4RKCNH2TAAR1POLBGAA | |
| SCHEMBL3348194 | 0.79 | KCNH2 (0.63) | MC4RKCNH2TAAR1POLBGAA | |
| SCHEMBL3353031 | 0.78 | KCNH2 (0.59) | KCNH2 | |
| SCHEMBL3353295 | 0.78 | GPR88 (0.52) | KCNH2 | |
| SCHEMBL22178742 | 0.77 | MC4R (0.88) | MC4RTAAR1POLBGAA | |
| SCHEMBL3353142 | 0.77 | MC4R (0.62) | MC4RSCN9ATAAR1POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | claimed |