Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 9/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3348887 | 0.86 | GRM5 (0.38) | GRM5DYRK1ACHRM2CHRM1 | |
| SCHEMBL3346840 | 0.86 | GRM5 (0.36) | GRM5KCNN3DYRK1A | |
| SCHEMBL3347219 | 0.85 | GRM5 (0.37) | GRM5DYRK1A | |
| SCHEMBL3346940 | 0.83 | GRM5 (0.42) | GRM5CYP2D6KCNH2 | |
| SCHEMBL3347525 | 0.81 | CHRNB2 (0.46) | GRM5CYP2D6 | |
| SCHEMBL3351121 | 0.78 | GRM5 (0.34) | GRM5KCNN3DYRK1A | |
| SCHEMBL3348895 | 0.78 | CHRM2 (0.40) | GRM5CYP2D6KCNN3DYRK1AKCNH2 | |
| SCHEMBL3348434 | 0.77 | GRM5 (0.54) | GRM5DYRK1AKCNH2 | |
| SCHEMBL3347283 | 0.77 | CYP2A6 (0.36) | GRM5DYRK1A | |
| SCHEMBL3345876 | 0.75 | GRM5 (0.53) | GRM5CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | claimed |
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |