Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 12/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3347641 | 0.89 | GRM5 (0.38) | GRM5SMN1; SMN2MAPK1KDM4EALDH1A1 | |
| SCHEMBL3345928 | 0.87 | GRM5 (0.36) | GRM5NPC1RAB9ASMN1; SMN2CYP2D6 | |
| SCHEMBL3345594 | 0.87 | GRM5 (0.40) | GRM5MAPK1KDM4EALDH1A1HTT | |
| SCHEMBL3346526 | 0.83 | GRM5 (0.37) | GRM5CYP2D6KCNH2 | |
| SCHEMBL3347306 | 0.82 | CHRNB2 (0.44) | GRM5CYP2D6CYP3A4 | |
| SCHEMBL3346926 | 0.81 | GRM5 (0.38) | GRM5MAPK1KDM4EALDH1A1HTT | |
| SCHEMBL3346856 | 0.81 | GRM5 (0.52) | GRM5NPC1RAB9ASMN1; SMN2CYP2D6 | |
| SCHEMBL3348338 | 0.79 | GRM5 (0.43) | GRM5NPC1RAB9ASMN1; SMN2CYP2D6 | |
| SCHEMBL3347664 | 0.79 | GRM5 (0.37) | GRM5MAPK1KDM4EALDH1A1HTT | |
| SCHEMBL3351706 | 0.78 | KDM4E (0.34) | GRM5MAPK1KDM4EALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |