Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.48 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.37 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 6/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.34 |
| ▸ | MC4R | P32245 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13365135 | 0.87 | KCNH2 (0.57) | KCNH2PDE2AACACB | |
| SCHEMBL13365050 | 0.87 | SSTR4 (0.39) | KCNH2SSTR4ROCK2ROCK1MC4R | |
| SCHEMBL13365134 | 0.85 | KCNH2 (0.64) | KCNH2SSTR4PDE2ATRPM8MC4R | |
| SCHEMBL3346452 | 0.85 | KCNH2 (0.48) | KCNH2SSTR4PDE2AROCK2ACACB | |
| SCHEMBL3346567 | 0.85 | KCNH2 (0.59) | KCNH2PDE2AACACB | |
| SCHEMBL3346572 | 0.83 | KCNH2 (0.51) | KCNH2PDE2AROCK2ROCK1ACACB | |
| SCHEMBL3353119 | 0.81 | KCNH2 (0.47) | KCNH2SSTR4PDE2AACACB | |
| SCHEMBL3346217 | 0.81 | KCNH2 (0.51) | KCNH2SSTR4PDE2AACACB | |
| SCHEMBL3345898 | 0.81 | KCNH2 (0.54) | KCNH2SSTR4HDAC4ROCK2ROCK1 | |
| SCHEMBL3346383 | 0.81 | KCNH2 (0.50) | KCNH2PDE2AROCK2ROCK1ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | claimed |
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | disclosed |