Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3348192 | 0.87 | KCNH2 (0.57) | KCNH2HDAC4TRPM8 | |
| SCHEMBL13365071 | 0.87 | KCNH2 (0.43) | KCNH2SSTR4ROCK2ROCK1 | |
| SCHEMBL13365134 | 0.85 | KCNH2 (0.64) | KCNH2TRPM8SSTR4 | |
| SCHEMBL3346204 | 0.85 | KCNH2 (0.54) | KCNH2HDAC4TRPM8SSTR4HRH3 | |
| SCHEMBL3415190 | 0.85 | KCNH2 (0.59) | KCNH2HDAC4HRH3P2RX7ROCK2 | |
| SCHEMBL3347928 | 0.83 | KCNH2 (0.53) | KCNH2HDAC4TRPM8ROCK2 | |
| SCHEMBL3346727 | 0.81 | KCNH2 (0.53) | KCNH2HDAC4TRPM8SSTR4HRH3 | |
| SCHEMBL3346554 | 0.81 | KCNH2 (0.48) | KCNH2HDAC4TRPM8SSTR4ROCK2 | |
| SCHEMBL3346410 | 0.81 | KCNH2 (0.48) | KCNH2SSTR4ROCK2 | |
| SCHEMBL3350867 | 0.81 | KCNH2 (0.52) | KCNH2TRPM8TRPV1P2RX7ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | claimed |
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | disclosed |