Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.43 |
| ▸ | OGA | O60502 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346603 | 0.82 | GRM5 (0.41) | GRM5OGADYRK1ATGFBR1SCN5A | |
| SCHEMBL3347027 | 0.79 | GRM5 (0.50) | GRM5DYRK1ATGFBR1KCNH2 | |
| SCHEMBL3348828 | 0.76 | TGFBR1 (0.39) | GRM5OGADYRK1ATGFBR1SCN5A | |
| SCHEMBL3347295 | 0.76 | GRM5 (0.48) | GRM5DYRK1A | |
| SCHEMBL3345917 | 0.75 | GRM5 (0.44) | GRM5OGADYRK1ATGFBR1SCN5A | |
| SCHEMBL3347519 | 0.74 | GRM4 (0.46) | GRM5DYRK1A | |
| SCHEMBL3347563 | 0.73 | GRM5 (0.36) | GRM5DYRK1ASCN5A | |
| SCHEMBL3347789 | 0.73 | GRM5 (0.49) | GRM5OGADYRK1ATGFBR1SCN5A | |
| SCHEMBL3345958 | 0.72 | GRM5 (0.52) | GRM5KCNH2 | |
| SCHEMBL3346766 | 0.72 | GRM5 (0.53) | GRM5TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | claimed |
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |