Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 4/20 | 0.66 |
| ▸ | JAK2 | O60674 | 3/20 | 0.66 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.66 |
| ▸ | AURKA | O14965 | 2/20 | 0.66 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.66 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.66 |
| ▸ | PLK4 | O00444 | 1/20 | 0.66 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.66 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.66 |
| ▸ | PRKCG | P05129 | 1/20 | 0.66 |
| ▸ | INSR | P06213 | 1/20 | 0.66 |
| ▸ | CDK1 | P06493 | 1/20 | 0.66 |
| ▸ | FES | P07332 | 1/20 | 0.66 |
| ▸ | IGF1R | P08069 | 1/20 | 0.66 |
| ▸ | ROS1 | P08922 | 1/20 | 0.66 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.66 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.66 |
| ▸ | FER | P16591 | 1/20 | 0.66 |
| ▸ | FLT1 | P17948 | 1/20 | 0.66 |
| ▸ | CDK2 | P24941 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3351160 | 0.81 | MAPK8 (0.56) | DYRK1AMAPK8AURKAAURKBCLK2 | |
| SCHEMBL3349599 | 0.81 | MAPK8 (0.56) | DYRK1AMAPK8AURKAAURKBMAPK9 | |
| SCHEMBL1516750 | 0.79 | JAK2 (1.00) | DYRK1AJAK2MAPK8AURKAAURKB | |
| SCHEMBL3351151 | 0.79 | MAPK8 (0.57) | DYRK1AMAPK8MAPK9MAPK10CLK1 | |
| SCHEMBL28614283 | 0.78 | JAK2 (0.75) | DYRK1AJAK2MAPK8AURKAAURKB | |
| SCHEMBL1516629 | 0.77 | DYRK1A (0.73) | DYRK1AJAK2MAPK8AURKAAURKB | |
| SCHEMBL8442334 | 0.77 | AXL (0.54) | DYRK1AMAPK8AURKAAURKBROCK2 | |
| SCHEMBL28610224 | 0.77 | DYRK1A (0.68) | DYRK1AJAK2MAPK8AURKAAURKB | |
| SCHEMBL27729491 | 0.76 | HTR1A (0.52) | CDK1IGF1RFLT1FLT4KDR | |
| SCHEMBL1516733 | 0.76 | DYRK1A (0.67) | DYRK1AJAK2MAPK8AURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150183781-A1 | 5-(1H-Pyrazol-4-yl)-1H-Pyrrolo[2,3-b]Pyridine Derivatives as Kinase Inhibitors | Um Pharmauji Sdn. Bhd. (MY) | 2015-07-02 | — | — | US | disclosed |
| EP-2882748-A1 | 5-(1H-PYRAZOL-4-YL)-1H-PYRROLO[2,3-b]PYRIDINE DERIVATIVES AS KINASE INHIBITORS | Aurigene Discovery Technologies Limited (IN) | 2015-06-17 | — | — | EP | disclosed |
| WO-2014024077-A1 | 5-(1H-PYRAZOL-4-YL)-1H-PYRROLO[2,3-b]PYRIDINE DERIVATIVES AS KINASE INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2014-02-13 | — | — | WO | disclosed |
| WO-2004078756-A2 | JNK INHIBITORS | EISAI CO., LTD. (JP) | 2004-09-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150183781-A1 | 5-(1H-Pyrazol-4-yl)-1H-Pyrrolo[2,3-b]Pyridine Derivatives as Kinase Inhibitors | MAP3K1, MAP3K5, MAP3K3 | DYRK1A 376/4885JAK2 241/4885MAPK8 166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.