Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.62 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 2/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7401143 | 0.88 | GPR119 (0.62) | GPR119HRH3MAPTPDE4APDE4B | |
| SCHEMBL3622118 | 0.87 | GPR119 (0.57) | GPR119HRH3PDE4APDE4BPDE4C | |
| SCHEMBL30102016 | 0.86 | GPR119 (0.64) | GPR119HRH3PDE4APDE4BPDE4C | |
| SCHEMBL1372747 | 0.86 | GPR119 (0.64) | GPR119HRH3PDE4APDE4BPDE4C | |
| SCHEMBL3343638 | 0.86 | GPR119 (0.64) | GPR119HRH3PDE4APDE4BPDE4C | |
| SCHEMBL20138026 | 0.85 | GPR119 (0.63) | GPR119PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5525265 | 0.85 | GPR119 (0.63) | GPR119HRH3PDE4APDE4BPDE4C | |
| SCHEMBL30812182 | 0.84 | GPR119 (0.50) | GPR119NPSR1MAPTPDE4APDE4B | |
| SCHEMBL601775 | 0.84 | DGAT1 (0.43) | GPR119HRH3MAPTPDE4BALDH1A1 | |
| SCHEMBL601774 | 0.84 | DGAT1 (0.43) | GPR119HRH3MAPTPDE4BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010048149-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2010-04-29 | — | — | WO | disclosed |
| WO-2010048149-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2010-04-29 | — | — | WO | disclosed |