Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.36 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.32 |
| ▸ | SPR | P35270 | 3/20 | 0.32 |
| ▸ | METAP2 | P50579 | 2/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346703 | 1.00 | DRD2 (0.36) | DRD2S1PR2FFAR4DRD4DRD3 | |
| SCHEMBL2424672 | 0.84 | GPR119 (0.42) | GRM5 | |
| SCHEMBL3384895 | 0.84 | DRD2 (0.47) | DRD2S1PR2FFAR4DRD4DRD3 | |
| SCHEMBL18446128 | 0.82 | DRD2 (0.39) | DRD2DRD4DRD3GRM5EPHX2 | |
| SCHEMBL2531711 | 0.79 | DRD2 (0.43) | DRD2S1PR2FFAR4DRD4DRD3 | |
| SCHEMBL2534239 | 0.78 | DRD2 (0.38) | DRD2S1PR2FFAR4DRD4DRD3 | |
| SCHEMBL2424675 | 0.74 | S1PR2 (0.33) | DRD2S1PR2FFAR4DRD4DRD3 | |
| SCHEMBL3387449 | 0.74 | S1PR2 (0.43) | DRD2S1PR2DRD4DRD3 | |
| SCHEMBL6153201 | 0.71 | METAP2 (0.38) | DRD2FFAR4DRD4DRD3SPR | |
| SCHEMBL3528321 | 0.70 | FFAR4 (0.40) | DRD2S1PR2FFAR4DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010058318-A1 | 1-OXA-8-AZASPIRO [4, 5 ] DECANE- 8 -CARBOXAMIDE COMPOUNDS AS FAAH INHIBITORS | PFIZER INC. (US) | 2010-05-27 | — | — | WO | disclosed |