Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.43 |
| ▸ | RAD52 | P43351 | 2/20 | 0.43 |
| ▸ | DRD4 | P21917 | 4/20 | 0.39 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | S100B | P04271 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3345906 | 0.83 | GAA (0.44) | GAARAD52IP6K1MAPTKDM4E | |
| SCHEMBL20128406 | 0.82 | PIK3CD (0.40) | GAARAD52DRD4IP6K1MAPT | |
| SCHEMBL30724195 | 0.81 | GAA (0.66) | GAARAD52DRD4MAPTKDM4E | |
| SCHEMBL15994391 | 0.80 | MAPT (0.46) | GAARAD52DRD4MAPTKDM4E | |
| SCHEMBL3346906 | 0.79 | SIRT6 (0.46) | GAAMAPTMAPK1ALDH1A1LMNA | |
| SCHEMBL10061499 | 0.78 | KDM4E (0.61) | GAARAD52MAPTKDM4EMAPK1 | |
| SCHEMBL2726089 | 0.77 | ALDH1A1 (0.48) | GAARAD52MAPTKDM4EMAPK1 | |
| SCHEMBL1712413 | 0.76 | CHKA (0.51) | GAARAD52DRD4MAPTKDM4E | |
| SCHEMBL3310366 | 0.76 | GFER (0.59) | GAAIP6K1MAPTKDM4EMAPK1 | |
| SCHEMBL1018073 | 0.76 | MAPT (0.61) | GAARAD52MAPTKDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010049731-A1 | PYRAZOLO- AND IMIDAZOPYRIDINYLPYRIMIDINEAMINES AS IGF-1R TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-05-06 | — | — | WO | disclosed |