Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 12/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3349619 | 0.84 | SIRT6 (0.47) | SIRT6MAPTALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL15994494 | 0.82 | MAPT (0.46) | SIRT6MAPTALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL22634636 | 0.82 | SIRT6 (0.68) | SIRT6MAPTALDH1A1L3MBTL1MAPK1 | |
| SCHEMBL18921192 | 0.81 | HPGD (0.62) | MAPTALDH1A1CYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL3346858 | 0.79 | GAA (0.43) | SIRT6MAPTALDH1A1L3MBTL1KMT2A | |
| SCHEMBL5054712 | 0.79 | MAPT (0.68) | MAPTALDH1A1KMT2APKMLMNA | |
| SCHEMBL15994800 | 0.79 | SIRT6 (0.69) | SIRT6MAPTALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL3314691 | 0.79 | MAPT (0.53) | SIRT6MAPTALDH1A1KMT2ALMNA | |
| SCHEMBL3632512 | 0.76 | CTSK (0.60) | SIRT6MAPTALDH1A1LMNAHTR1A | |
| SCHEMBL3346276 | 0.75 | MAPT (0.55) | SIRT6MAPTALDH1A1L3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010049731-A1 | PYRAZOLO- AND IMIDAZOPYRIDINYLPYRIMIDINEAMINES AS IGF-1R TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-05-06 | — | — | WO | disclosed |