Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | OGA | O60502 | 1/20 | 0.35 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346551 | 0.86 | DYRK1A (0.35) | KMT2AOGADYRK1APCSK9SCN5A | |
| SCHEMBL3347627 | 0.85 | OGA (0.38) | FLT4OGADYRK1APCSK9SCN5A | |
| SCHEMBL29090207 | 0.71 | GRM5 (0.44) | FLT4KMT2ANPSR1 | |
| SCHEMBL29090196 | 0.71 | GRM5 (0.44) | FLT4KMT2ANPSR1 | |
| SCHEMBL3346885 | 0.71 | OGA (0.38) | OGADYRK1APCSK9SCN5ATGFBR1 | |
| SCHEMBL3345883 | 0.71 | DYRK1A (0.37) | OGADYRK1ASCN5ATGFBR1 | |
| SCHEMBL3347276 | 0.70 | DYRK1A (0.35) | OGADYRK1APCSK9SCN5ATGFBR1 | |
| SCHEMBL3346192 | 0.70 | GRM5 (0.47) | OGADYRK1ASCN5ATGFBR1TSHR | |
| SCHEMBL3346766 | 0.69 | GRM5 (0.53) | KMT2ATGFBR1CYP3A4CYP2C19 | |
| SCHEMBL3346384 | 0.68 | GRM5 (0.43) | KMT2AOGADYRK1ATGFBR1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | claimed |
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |