Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 2/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3351783 | 0.90 | NPC1 (0.44) | NPC1POLBRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL3377466 | 0.89 | MAOB (0.40) | ALDH1A1MAPTHTTNPC1POLB | |
| SCHEMBL3345433 | 0.81 | CSF1R (0.41) | CSF1RALDH1A1KDM4E | |
| SCHEMBL3102544 | 0.69 | JAK2 (0.35) | CSF1RPARP1 | |
| SCHEMBL15495478 | 0.68 | LMNA (0.47) | ALDH1A1MAPTHTTNPC1POLB | |
| SCHEMBL30849274 | 0.68 | PARP1 (0.71) | ALDH1A1MAPTHTTNPC1RAB9A | |
| SCHEMBL21179152 | 0.67 | CYP1A2 (0.46) | CSF1RALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14845158 | 0.67 | AURKA (0.44) | PLK1ALDH1A1MAPTHTTNPC1 | |
| SCHEMBL3091352 | 0.66 | KDM4E (0.41) | ALDH1A1HTTRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL29322211 | 0.65 | HTT (0.47) | ALDH1A1MAPTHTTNPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010045987-A1 | SUBSTITUTED (AZA) -1-METHYL-1H-QUIN0LIN-2-0NES AS ANTIBACTERIALS | GLAXO GROUP LIMITED (GB) | 2010-04-29 | — | — | WO | disclosed |
| WO-2010046388-A1 | SUBSTITUTED (AZA) -1-METHYL-1H-QUINOLIN-2-ONES AS ANTIBACTERIALS | GLAXO GROUP LIMITED (GB) | 2010-04-29 | — | — | WO | disclosed |