Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ASPH | Q12797 | 1/20 | 0.39 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.39 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346955 | 0.90 | PLK1 (0.42) | NPC1POLBRAB9ASMN1; SMN2ALKBH1 | |
| SCHEMBL3377466 | 0.90 | MAOB (0.40) | NPC1POLBRAB9ASMN1; SMN2ALKBH1 | |
| SCHEMBL3345433 | 0.81 | CSF1R (0.41) | KDM4EPIK3CD | |
| SCHEMBL21679225 | 0.70 | RAB9A (0.54) | NPC1POLBRAB9ASMN1; SMN2ALKBH1 | |
| SCHEMBL9356673 | 0.70 | RAB9A (0.56) | NPC1POLBRAB9ASMN1; SMN2PLA2G4B | |
| SCHEMBL691628 | 0.69 | RAB9A (0.55) | NPC1POLBRAB9ASMN1; SMN2PLA2G4B | |
| SCHEMBL14699947 | 0.69 | NPC1 (0.55) | NPC1POLBRAB9ASMN1; SMN2PLA2G4B | |
| SCHEMBL15680345 | 0.68 | NPC1 (0.48) | NPC1POLBRAB9ASMN1; SMN2ALKBH1 | |
| SCHEMBL14699822 | 0.68 | SMN1; SMN2 (0.54) | NPC1POLBRAB9ASMN1; SMN2PTPN1 | |
| SCHEMBL21179152 | 0.68 | CYP1A2 (0.46) | NPC1RAB9ASMN1; SMN2MAOBHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010046388-A1 | SUBSTITUTED (AZA) -1-METHYL-1H-QUINOLIN-2-ONES AS ANTIBACTERIALS | GLAXO GROUP LIMITED (GB) | 2010-04-29 | — | — | WO | disclosed |
| WO-2010045987-A1 | SUBSTITUTED (AZA) -1-METHYL-1H-QUIN0LIN-2-0NES AS ANTIBACTERIALS | GLAXO GROUP LIMITED (GB) | 2010-04-29 | — | — | WO | disclosed |