Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3351783 | 0.90 | NPC1 (0.44) | MAOBHDAC8FFAR1KDM4ESMN1; SMN2 | |
| SCHEMBL3346955 | 0.89 | PLK1 (0.42) | MAOBHDAC8ALDH1A1HTTMAPT | |
| SCHEMBL3345433 | 0.81 | CSF1R (0.41) | NPBWR1MCHR1ALDH1A1KDM4E | |
| SCHEMBL3091352 | 0.75 | KDM4E (0.41) | ALDH1A1HTTKDM4ESMN1; SMN2RAB9A | |
| SCHEMBL3095482 | 0.74 | TSHR (0.42) | ALDH1A1HTTMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL3104419 | 0.71 | ALDH1A1 (0.38) | ALDH1A1HTTMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL14699870 | 0.69 | FFAR4 (0.46) | HDAC8ALDH1A1HTTMAPTFFAR1 | |
| SCHEMBL23512705 | 0.68 | FFAR4 (0.51) | HDAC8ALDH1A1HTTMAPTFFAR1 | |
| SCHEMBL14699786 | 0.68 | MAPT (0.48) | HDAC8ALDH1A1HTTMAPTFFAR1 | |
| SCHEMBL22120001 | 0.68 | MAOB (0.46) | MAOBALDH1A1HTTMAPTFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010045987-A1 | SUBSTITUTED (AZA) -1-METHYL-1H-QUIN0LIN-2-0NES AS ANTIBACTERIALS | GLAXO GROUP LIMITED (GB) | 2010-04-29 | — | — | WO | disclosed |
| WO-2010046388-A1 | SUBSTITUTED (AZA) -1-METHYL-1H-QUINOLIN-2-ONES AS ANTIBACTERIALS | GLAXO GROUP LIMITED (GB) | 2010-04-29 | — | — | WO | disclosed |