Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | OGA | O60502 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | PRKDC | P78527 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346993 | 0.85 | GRM5 (0.51) | GRM5FFAR1 | |
| SCHEMBL3345830 | 0.82 | FFAR1 (0.40) | GRM5OGAFFAR1CYP3A4PDGFRB | |
| SCHEMBL4713709 | 0.78 | GRM5 (0.66) | GRM5ALDH1A1CYP3A4 | |
| SCHEMBL3346995 | 0.77 | GRM5 (0.56) | GRM5OGAALDH1A1PDGFRBKDR | |
| SCHEMBL3346980 | 0.75 | GRM5 (0.49) | GRM5ALDH1A1CYP3A4PDGFRBKDR | |
| SCHEMBL3347573 | 0.75 | GRM5 (0.58) | GRM5 | |
| SCHEMBL3346401 | 0.74 | ALDH1A1 (0.50) | GRM5ALDH1A1FFAR1IDH1CYP3A4 | |
| SCHEMBL3346805 | 0.73 | DYRK1A (0.43) | GRM5FFAR1 | |
| SCHEMBL3347261 | 0.73 | GRM5 (0.47) | GRM5 | |
| SCHEMBL3351351 | 0.72 | FFAR1 (0.39) | GRM5OGAALDH1A1FFAR1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | claimed |
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |