Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.56 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 3/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | INSR | P06213 | 1/20 | 0.39 |
| ▸ | LYN | P07948 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | ROS1 | P08922 | 1/20 | 0.39 |
| ▸ | FGR | P09769 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | TIE1 | P35590 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17358798 | 0.74 | RIPK1 (0.61) | RIPK1MAOBMAOALMNAJAK2 | |
| SCHEMBL17358800 | 0.74 | RIPK1 (0.61) | RIPK1MAOBMAOALMNAJAK2 | |
| SCHEMBL28167683 | 0.74 | RIPK1 (0.58) | RIPK1MAOBJAK2NTRK1PDE5A | |
| SCHEMBL8100567 | 0.73 | RIPK1 (0.36) | RIPK1LMNA | |
| SCHEMBL8109474 | 0.73 | CYP19A1 (0.41) | RIPK1 | |
| SCHEMBL27112626 | 0.72 | CHRNB2 (0.64) | RIPK1LMNA | |
| SCHEMBL21859861 | 0.72 | CHRNB2 (0.64) | RIPK1LMNA | |
| SCHEMBL4292933 | 0.72 | CHRNB2 (0.64) | RIPK1LMNA | |
| SCHEMBL19275745 | 0.72 | RIPK1 (0.58) | RIPK1MAOBMAOALMNATSHR | |
| SCHEMBL17067869 | 0.70 | RIPK1 (0.73) | RIPK1LMNAJAK2NTRK1PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010048314-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2010-04-29 | — | — | WO | disclosed |