Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 6/20 | 0.58 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 3/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17881986 | 0.82 | RIPK1 (0.80) | RIPK1PDE5AJAK2NTRK1OPRK1 | |
| SCHEMBL17881960 | 0.77 | RIPK1 (0.71) | RIPK1PDE5ADRD4 | |
| SCHEMBL3347010 | 0.74 | RIPK1 (0.56) | RIPK1PDE5AJAK2NTRK1MAOB | |
| SCHEMBL17067870 | 0.74 | RIPK1 (0.73) | RIPK1PDE5AJAK2NTRK1OPRK1 | |
| SCHEMBL17067869 | 0.74 | RIPK1 (0.73) | RIPK1PDE5AJAK2NTRK1OPRK1 | |
| SCHEMBL469686 | 0.74 | RIPK1 (0.73) | RIPK1PDE5AJAK2NTRK1OPRK1 | |
| SCHEMBL19275745 | 0.73 | RIPK1 (0.58) | RIPK1OPRK1OPRM1OPRD1MAOB | |
| SCHEMBL17358798 | 0.71 | RIPK1 (0.61) | RIPK1PDE5AJAK2NTRK1MAOB | |
| SCHEMBL28167652 | 0.71 | RIPK1 (0.73) | RIPK1JAK2NTRK1OPRK1OPRM1 | |
| SCHEMBL17358800 | 0.71 | RIPK1 (0.61) | RIPK1PDE5AJAK2NTRK1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107108492-A | Inhibitor of cellular necrosis | 北京生命科学研究所 | 2017-08-29 | — | — | CN | disclosed |