Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 8/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3347174 | 0.89 | ALOX5 (0.36) | GRM5KDM4EALDH1A1MAPK1HTT | |
| SCHEMBL3345574 | 0.87 | GRM5 (0.34) | GRM5CHRM2CHRM1KDM4EALDH1A1 | |
| SCHEMBL3345895 | 0.84 | CA12 (0.35) | GRM5CHRM2CHRM1KDM4EALDH1A1 | |
| SCHEMBL3346865 | 0.81 | CHRM2 (0.35) | GRM5PTGDR2CHRM2CHRM1 | |
| SCHEMBL3348338 | 0.81 | GRM5 (0.43) | GRM5CHRM2CHRM1NPC1RAB9A | |
| SCHEMBL3347237 | 0.81 | GRM5 (0.46) | GRM5 | |
| SCHEMBL3345981 | 0.80 | GRM5 (0.52) | GRM5 | |
| SCHEMBL3346926 | 0.79 | GRM5 (0.38) | GRM5KDM4EALDH1A1MAPK1HTT | |
| SCHEMBL3346728 | 0.79 | GRM5 (0.38) | GRM5KDM4EALDH1A1MAPK1HTT | |
| SCHEMBL3346517 | 0.78 | GRM5 (0.34) | GRM5CHRM2CHRM1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | claimed |
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |