Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 13/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346728 | 0.89 | GRM5 (0.38) | GRM5CHRNB2CHRNA4 | |
| SCHEMBL3345895 | 0.88 | CA12 (0.35) | GRM5NPC1RAB9ASMN1; SMN2CHRM2 | |
| SCHEMBL3344268 | 0.87 | ADORA2B (0.40) | GRM5CHRM2CHRM1CHRNB2CHRNA4 | |
| SCHEMBL3348895 | 0.83 | CHRM2 (0.40) | GRM5CHRM2CHRM1CYP2D6KCNH2 | |
| SCHEMBL3347152 | 0.83 | CHRNB2 (0.41) | GRM5CYP2D6CYP3A4CHRNB2CHRNA4 | |
| SCHEMBL3347334 | 0.81 | GRM5 (0.37) | GRM5NPC1RAB9ASMN1; SMN2CHRM2 | |
| SCHEMBL3345981 | 0.81 | GRM5 (0.52) | GRM5 | |
| SCHEMBL3348419 | 0.79 | GRM5 (0.36) | GRM5CHRM2CHRM1 | |
| SCHEMBL3346940 | 0.79 | GRM5 (0.42) | GRM5NPC1RAB9ASMN1; SMN2CYP2D6 | |
| SCHEMBL3347174 | 0.79 | ALOX5 (0.36) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | claimed |
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |