Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3347568 | 0.87 | GRM5 (0.38) | GRM5TGFBR1 | |
| SCHEMBL3347598 | 0.82 | GRM5 (0.58) | GRM5DYRK1ACYP11B2 | |
| SCHEMBL3351280 | 0.82 | GRM5 (0.47) | GRM5DYRK1A | |
| SCHEMBL3347563 | 0.78 | GRM5 (0.36) | GRM5DYRK1A | |
| SCHEMBL3347295 | 0.76 | GRM5 (0.48) | GRM5DYRK1A | |
| SCHEMBL3348828 | 0.76 | TGFBR1 (0.39) | GRM5TGFBR1DYRK1A | |
| SCHEMBL3346603 | 0.74 | GRM5 (0.41) | GRM5TGFBR1DYRK1A | |
| SCHEMBL3351358 | 0.74 | CYP11B2 (0.40) | GRM5CYP11B2CSNK1A1CSNK1DGSK3B | |
| SCHEMBL3347498 | 0.71 | GRM5 (0.41) | GRM5 | |
| SCHEMBL3347519 | 0.70 | GRM4 (0.46) | GRM5DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | claimed |
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |