SCHEMBL3347895

SCHEMBL3347895

Cc1cc(-c2cccs2)cc(N2CCN(C)CC2)n1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 1/20 0.61
HTR6 P50406 1/20 0.61
HTR3E A5X5Y0 1/20 0.51
HTR3B O95264 1/20 0.51
HTR3A P46098 1/20 0.51
HTR3D Q70Z44 1/20 0.51
HTR3C Q8WXA8 1/20 0.51
ALDH1A1 P00352 2/20 0.49
POLB P06746 1/20 0.49
RIPK3 Q9Y572 1/20 0.47
KDM4E B2RXH2 1/20 0.46
MAPK1 P28482 1/20 0.46
LMNA P02545 1/20 0.45
GBA1 P04062 1/20 0.45
KMT2A Q03164 2/20 0.45
MEN1 O00255 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
NPSR1 Q6W5P4 1/20 0.44
HRH4 Q9H3N8 1/20 0.44
HDAC3 O15379 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3349828 0.80 HTR6 (0.68) DRD2HTR6HTR3EHTR3BHTR3A
SCHEMBL2386000 0.79 RIPK3 (0.53) HTR3AALDH1A1POLBRIPK3KDM4E
SCHEMBL13377770 0.78 SMN1; SMN2 (0.50) ALDH1A1POLBKDM4EMAPK1LMNA
SCHEMBL3347950 0.76 HTR6 (1.00) DRD2HTR6HTR3EHTR3BHTR3A
SCHEMBL2385681 0.75 KDM4E (0.69) HTR6ALDH1A1POLBKDM4EMAPK1
SCHEMBL2383641 0.75 POLB (0.56) ALDH1A1POLBKDM4EMAPK1LMNA
SCHEMBL3350651 0.75 DRD2 (0.57) DRD2HTR6HTR3EHTR3BHTR3A
SCHEMBL3346394 0.74 DRD2 (0.64) DRD2HTR6HTR3EHTR3BHTR3A
SCHEMBL2385728 0.74 ALDH1A1 (0.54) HTR3EHTR3BHTR3AHTR3DHTR3C
SCHEMBL2385074 0.72 ALDH1A1 (0.63) HTR3EHTR3BHTR3AHTR3DHTR3C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010053388-A1 NEW 4,6-DISUBSTITUTED 2-(4-METHYLPIPERAZIN-1-YL)PYRIDINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITION CONTAINING THESE COMPOUNDS, THEIR USE, A METHOD FOR MODULATING MONOAMINERGIC RECEPTOR ACTIVITY AND A MONOAMINERGIC RECEPTOR MODULATING AGENT INSTYTUT FARMAKOLOGII POLSKIEJ AKADEMII NAUK (PL) 2010-05-14 WO claimed
WO-2010053388-A1 NEW 4,6-DISUBSTITUTED 2-(4-METHYLPIPERAZIN-1-YL)PYRIDINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITION CONTAINING THESE COMPOUNDS, THEIR USE, A METHOD FOR MODULATING MONOAMINERGIC RECEPTOR ACTIVITY AND A MONOAMINERGIC RECEPTOR MODULATING AGENT INSTYTUT FARMAKOLOGII POLSKIEJ AKADEMII NAUK (PL) 2010-05-14 WO disclosed