Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 5/20 | 0.75 |
| ▸ | CTSK | P43235 | 5/20 | 0.75 |
| ▸ | CTSL | P07711 | 4/20 | 0.75 |
| ▸ | CTSV | O60911 | 2/20 | 0.75 |
| ▸ | PLAT | P00750 | 2/20 | 0.75 |
| ▸ | CTSH | P09668 | 2/20 | 0.75 |
| ▸ | CASP14 | P31944 | 2/20 | 0.75 |
| ▸ | CASP6 | P55212 | 2/20 | 0.75 |
| ▸ | CTSZ | Q9UBR2 | 2/20 | 0.75 |
| ▸ | CTSB | P07858 | 3/20 | 0.67 |
| ▸ | CASP4 | P49662 | 1/20 | 0.63 |
| ▸ | CASP5 | P51878 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346441 | 0.86 | CTSS (0.75) | CTSSCTSKCTSLCTSVPLAT | |
| SCHEMBL3350907 | 0.86 | CTSS (1.00) | CTSSCTSKCTSLCTSVPLAT | |
| SCHEMBL3346331 | 0.81 | CTSL (0.98) | CTSSCTSKCTSLCTSVPLAT | |
| SCHEMBL3347831 | 0.78 | CTSS (1.00) | CTSSCTSKCTSLCTSVPLAT | |
| SCHEMBL6241632 | 0.76 | CTSS (0.68) | CTSSCTSKCTSLCTSVPLAT | |
| SCHEMBL7564951 | 0.74 | KDR (0.58) | — | |
| SCHEMBL7793289 | 0.73 | TDP1 (0.49) | CASP6 | |
| SCHEMBL27224015 | 0.72 | MERTK (0.65) | — | |
| SCHEMBL30896246 | 0.72 | MERTK (0.65) | — | |
| SCHEMBL4835437 | 0.71 | CTSL (0.41) | CTSSCTSKCTSLCTSVPLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059418-A1 | SUBSTITUTED TRIAZINE AND PURINE COMPOUNDS, METHODS OF INHIBITING CRUZAIN AND RHODESAIN AND METHODS OF TREATING CHAGAS DISEASE AND AFRICAN TRYPANOSOMIASIS | THE GOVERNMENT OF THE U.S.A. AS REPRESENTED BY THE SECRETARY OF THE DEPT. OF HEALTH & HUMAN SERVICES (US) | 2010-05-27 | — | — | WO | disclosed |